Topic
Pyranose
About: Pyranose is a research topic. Over the lifetime, 1619 publications have been published within this topic receiving 35348 citations. The topic is also known as: pyranoses & hexopyranose.
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TL;DR: In this article, the gulo and allo structures of 6-deoxy-2,3- O -isopropylidene-α-D -hexopyranosides have been compared.
8 citations
TL;DR: Intramolecular Friedel-Crafts cyclization of 2-O-benzyl ethers at a model pyranose acetal is activated by incorporation of a trimethylsilyl group, albeit via unexpected, presumably steric means.
8 citations
TL;DR: The crystal structures of α-D-glucosamine hydrochloride and hydrobromide have been determined and refined from the original experimental data as mentioned in this paper, and the most interesting feature of these new results is now the inter-ionic hydrogen-bonding, which is dominated by the co-ordination about the NH 3 + groups and the anions.
Abstract: The crystal structures of α-D-glucosamine hydrochloride and hydrobromide have been redetermined and refined from the original experimental data. The pyranose ring of the sugar molecule has the expected normal Sachse trans configuration with the lower energy conformation 1 a 2 e 3 e 4 e 5 e . The most interesting feature of these new results is now the inter-ionic hydrogen-bonding, which is dominated by the co-ordination about the NH 3 + groups and the anions.
8 citations
Patent•
12 Nov 2004TL;DR: In this article, the authors proposed a novel hydroxy piperidine (HP) derivatives having a positive charge at the position corresponding to the anomeric position of a pyranose ring.
Abstract: The present invention provides novel hydroxy piperidine (HP) derivatives having (i) a positive charge at the position corresponding to the anomeric position of a pyranose ring; (ii) a short, flexible linker emanating from the corresponding position of the ring oxygen in a pyranose; and (iii) a lipophilic moiety connected to the linker and pharmaceutically acceptable salts thereof The linker can be absent if the lipophilic moiety corresponds to a hydrocarbon chain with a linear length of 6 or more carbons The present invention further provides a method for treating individuals having Gaucher disease by administering the novel HP derivative as 'chaperones' for the mutant glucocerebrosidase associated with the disease
8 citations
TL;DR: The major tautomers of D-fructose in water are the β-pyranose and β-furanose forms, the former predominating as discussed by the authors.
Abstract: The major tautomers of D-fructose in water are the β-pyranose and β-furanose forms, the former predominating. NMR studies have shown that when aqueous DNA is added, there is a shift in the β-pyranose ⇌β-furanose equilibrium, the latter form being favoured. It is suggested that this is caused by weak, preferential binding of the β-furanose form to DNA. This is supported by computer modelling, which shows that for the former, only two hydrogen bonds can be formed between sugar O–H groups and phosphate units, whereas three good bonds can be formed with the latter.Studies of the O–1H resonances of the anomeric groups of the two forms confirm this change in equilibrium. In addition this feature for the β-furanose form shifts to low-field without significant broadening. This indicates that strong hydrogen bonding to DNA occurs, but that the equilibrium is very rapid giving fast averaging of the NMR signals.
8 citations