Topic
Pyrazoline
About: Pyrazoline is a research topic. Over the lifetime, 2041 publications have been published within this topic receiving 22933 citations. The topic is also known as: 4,5-dihydro-3H-pyrazole.
Papers published on a yearly basis
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TL;DR: It was found that 4-methoxy and 4-chloro substituent on the phenyl ring at position 3 of the pyrazoline ring increased the antidepressant activity; the replacement of these groups by bromo and methyl substituents decreased activity in mice.
293 citations
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TL;DR: The hypsochromic shift in the emission of DAP nanoparticles was identified as originating from the pronounced decrease in the Stokes shift due to the restraint of vibronic relaxation and the configuration reorganization induced by the increased intermolecular interaction.
Abstract: Organic nanoparticles of 1,3-diphenyl-5-(2-anthryl)-2- pyrazoline (DAP) ranging in average diameters from 40 to 160 nm were prepared through the reprecipitation method. The average diameters of the particles were controlled by variation of the aging time. We found that DAP nanoparticles exhibit the size-dependent optical properties. The absorption transitions of the nanoparticles at the lower-energy side experience a bathochromic shift with an increase in the particle size as a result of the increased intermolecular interactions, while the higher-energy bands of anthracene split possibly due to the electronic coupling between the pyrazoline ring of one molecule and the anthracene moiety of the neighboring molecule. Most interestingly, the nanoparticle emission in the blue light region from pyrazoline chromophore shifts to shorter wavelengths with an increase in the particle size, accompanied with a relatively gradual dominance of the emission at about 540 nm from an exciplex between the pyrazoline ring of...
261 citations
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TL;DR: The most efficient anticancer compound 16 was found to be active with selective influence on colon cancer cell lines, especially on HT 29 (logGI(50)=-6.37) and in vitro anticancer activity of synthesized compounds were tested by the National Cancer Institute.
246 citations
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TL;DR: In general, the oxidized pyrazoles displayed better antitumor activity than their parent pyrazoline analogs, whereas the benzenesulfonamides and the N1, N3-disubstituted sulfonylureas showed significant better antitUMor spectrum than the sulfonyLthioureido and the derived thiazole analogs.
224 citations
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TL;DR: Among the compounds studied, compound 2e showed more potent anti-inflammatory and analgesic activity than the standard drug, along with minimum ulcerogenic index.
221 citations