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Pyridine

About: Pyridine is a research topic. Over the lifetime, 39783 publications have been published within this topic receiving 561908 citations. The topic is also known as: azabenzene & azine.


Papers
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Journal ArticleDOI
TL;DR: Two catalytic protocols of the oxidative C-C bond formation have been developed on the basis of the C-H bond activation of pyridine N-oxides and their corresponding ortho-alkenylated N-oxide derivatives are obtained in good to excellent yields.
Abstract: Two catalytic protocols of the oxidative C−C bond formation have been developed on the basis of the C−H bond activation of pyridine N-oxides. Pd-catalyzed alkenylation of the N-oxides proceeds with excellent regio-, stereo-, and chemoselectivity, and the corresponding ortho-alkenylated N-oxide derivatives are obtained in good to excellent yields. Direct cross-coupling reaction of pyridine N-oxides with unactivated arene was also developed in the presence of Pd catalyst and Ag oxidant, which affords ortho-arylated pyridine N-oxide products with high site-selectivity.

605 citations

Journal ArticleDOI
TL;DR: In this article, the main qualitative differences between the spectra of pyridine, co-ordinated Pyridine and the pyridinium ion are discussed and an assignment is made for all the bands observed in the spectrum of co-coordinated pyridium.

568 citations

Journal ArticleDOI
TL;DR: Evidence is presented suggesting that the treated cells underwent programmed cell death through a p53-dependent pathway, and while the palladium complexes 1a and 1b displayed potent anticancer activity, the gold and silver complexes exhibited significant antimicrobial properties.
Abstract: Complete synthetic, structural, and biomedical studies of two Pd complexes as well as Au and Ag complexes of 1-benzyl-3-tert-butylimidazol-2-ylidene are reported. Specifically, trans-[1-benzyl-3-tert-butylimidazol-2-ylidene]Pd(pyridine)Cl2 (1a) was synthesized from the reaction of 1-benzyl-3-tert-butylimidazolium chloride (1) with PdCl2 in the presence of K2CO3 as a base. The other palladium complex, [1-benzyl-3-tert-butylimidazol-2-ylidene]2PdCl2 (1b), and a gold complex, [1-benzyl-3-tert-butylimidazol-2-ylidene]AuCl (1c), were synthesized by following a transmetallation route from the silver complex, [1-benzyl-3-tert-butylimidazol-2-ylidene]AgCl (1d), by treatment with (COD)PdCl2 and (SMe2)AuCl, respectively. The silver complex 1d in turn was synthesized by the reaction of 1 with Ag2O. The molecular structures of 1a−d have been determined by X-ray diffraction studies. Biomedical studies revealed that, while the palladium complexes 1a and 1b displayed potent anticancer activity, the gold (1c) and silver ...

563 citations

Journal ArticleDOI
TL;DR: The relatively stable white solid tris(pentafluorophenyl)boron has been prepared in high yield from boron trichloride and pentafluorsyllithium using pentane as a solvent.

553 citations

Journal ArticleDOI
TL;DR: This Account outlines recent advances in asymmetric hydrogenation of heteroaromatic compounds, including indole, quinoline, isoquinoline, furan, and pyridine derivatives, using chiral organometallic catalysts and organocatalysts.
Abstract: Asymmetric hydrogenation of heteroaromatic compounds has emerged as a promising new route to saturated or partially saturated chiral heterocyclic compounds. In this Account, we outline recent advances in asymmetric hydrogenation of heteroaromatic compounds, including indole, quinoline, isoquinoline, furan, and pyridine derivatives, using chiral organometallic catalysts and organocatalysts.

536 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023904
20221,820
2021622
2020767
2019897
2018910