Topic
Pyrroline
About: Pyrroline is a research topic. Over the lifetime, 836 publications have been published within this topic receiving 9828 citations. The topic is also known as: pyrrolines & dihydropyrrole.
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TL;DR: The methods used for the synthesis of vicinal diaryl-substituted pyrrole, pyrroline and pyrrolidine derivatives are reviewed in this article, which contains 461 references and summarizes bioactivity data of some of these compounds.
532 citations
221 citations
TL;DR: The unstable metabolic intermediate 1Δ-pyrroline-5-car☐ylic acid (P5C or glutamic semialdehyde) can be isolated as a chemically pure solid by preparing it in dilute solution by periodate oxidation of dl-hydroxylysine and isolating it as a pure 2,4-dinitrophenylhydrazone from which P5C can be quantitatively regenerated.
159 citations
TL;DR: This strategy provides a novel catalytic cycle for alkene carboimination through a sequence comprising N-radical generation, iminyl radical cyclization, intermolecular conjugate addition to a Michael acceptor, and single-electron reduction to afford various pyrroline derivatives in an overall redox-neutral process.
Abstract: The visible-light-promoted decarboxylation of α-imino-oxy propionic acids for the generation of iminyl radicals has been accomplished through the use of Ir(dFCF3 ppy)2 (dtbbpy)PF6 as a photoredox catalyst. Different from visible-light-promoted homolysis and single-electron reduction of oxime derivatives, this strategy provides a novel catalytic cycle for alkene carboimination through a sequence comprising N-radical generation, iminyl radical cyclization, intermolecular conjugate addition to a Michael acceptor, and single-electron reduction to afford various pyrroline derivatives in an overall redox-neutral process. The indolizidine alkaloid skeleton could be easily constructed from a pyrroline derivative prepared by this synthetic method.
152 citations