Topic
Pyruvate dehydrogenase kinase
About: Pyruvate dehydrogenase kinase is a research topic. Over the lifetime, 4224 publications have been published within this topic receiving 161052 citations. The topic is also known as: [pyruvate dehydrogenase (lipoamide)] kinase & pyruvate dehydrogenase (lipoamide) kinase.
Papers published on a yearly basis
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TL;DR: The physical, chemical, immunologie and kinetic properties of the four isozymes of pyruvate kinase are tabulated, finding the L- and R-isozymes are kinetically similar and immunologically cross-reactive with the M 1 -isozyme.
146 citations
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TL;DR: The rate of pyruvate transfer into mitochondria is of primary importance in the control of mitochondrial CO2 fixation, and the primary role of mitochondrial pyruVate uptake was confirmed.
146 citations
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TL;DR: Molecular cloning of pyruvate dehydrogenase kinase establishes a new eukaryotic family of protein kinases that is related to a prokaryoticFamily ofprotein kinases.
146 citations
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145 citations
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TL;DR: A model for the flip-flop action of this enzyme is proposed through a concerted ∼2-Å shuttle-like motion of its heterodimers, suggesting that this newly defined shuttle- like motion of domains is common to the family of thiamin pyrophosphate-dependent enzymes.
144 citations