scispace - formally typeset
Search or ask a question
Topic

Pyruvate dehydrogenase kinase

About: Pyruvate dehydrogenase kinase is a research topic. Over the lifetime, 4224 publications have been published within this topic receiving 161052 citations. The topic is also known as: [pyruvate dehydrogenase (lipoamide)] kinase & pyruvate dehydrogenase (lipoamide) kinase.


Papers
More filters
Journal ArticleDOI
TL;DR: The physical, chemical, immunologie and kinetic properties of the four isozymes of pyruvate kinase are tabulated, finding the L- and R-isozymes are kinetically similar and immunologically cross-reactive with the M 1 -isozyme.

146 citations

Journal ArticleDOI
TL;DR: The rate of pyruvate transfer into mitochondria is of primary importance in the control of mitochondrial CO2 fixation, and the primary role of mitochondrial pyruVate uptake was confirmed.

146 citations

Journal ArticleDOI
TL;DR: Molecular cloning of pyruvate dehydrogenase kinase establishes a new eukaryotic family of protein kinases that is related to a prokaryoticFamily ofprotein kinases.

146 citations

Journal ArticleDOI
TL;DR: A model for the flip-flop action of this enzyme is proposed through a concerted ∼2-Å shuttle-like motion of its heterodimers, suggesting that this newly defined shuttle- like motion of domains is common to the family of thiamin pyrophosphate-dependent enzymes.

144 citations


Network Information
Related Topics (5)
Mitochondrion
51.5K papers, 3M citations
87% related
Protein kinase A
68.4K papers, 3.9M citations
86% related
Phosphorylation
69.3K papers, 3.8M citations
85% related
Endoplasmic reticulum
48.3K papers, 2.4M citations
84% related
Intracellular
41.4K papers, 1.8M citations
84% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202329
202234
202161
202063
201959
201851