Topic
Pyruvate kinase
About: Pyruvate kinase is a research topic. Over the lifetime, 5683 publications have been published within this topic receiving 180020 citations. The topic is also known as: ATP:pyruvate 2-O-phosphotransferase & phosphoenolpyruvate kinase.
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TL;DR: A fluorescence methodology to measure G6P concentrations in cell extracts based on the reaction of glucose-6-phosphate and the diaphorase-resazurin amplifying system is developed, illustrating an in vitro Warburg-like effect on cell metabolism.
60 citations
TL;DR: In hemolytic anemia associated with hexokinase or pyruvate kinase deficiency, activities of these enzymes measured in patient erythrocytes appeared to be close to the calculated critical values, but it was shown that in phosphofructokinase, glucosephosphate isomerase, trioseph phosphate isomersase, or phosphoglycerate kinases deficiency, hemolytics anemia can arise because of the instability ofThese enzymes in time.
60 citations
60 citations
TL;DR: It is shown that PKM2 was overexpressed in gastric tumor tissues compared to normal tissues and its expression level was associated with poor survival of gastric cancer patients, and PKM1 may function as an upstream molecule that regulates p65 function and thus enhances the growth of tumor cells.
60 citations
TL;DR: Fully understanding the mechanisms underlying the Warburg effect should provide new approaches to cancer treatment, as it is shown that increased lactate caused by increased glycolysis in cancer cells leads to cancer spread.
60 citations