Topic
Quality of life
About: Quality of life is a research topic. Over the lifetime, 42912 publications have been published within this topic receiving 1198363 citations. The topic is also known as: life quality.
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TL;DR: An improvement in QOL indices was globally observed; this improvement was much more marked in men than in women, for unclear reasons, and older age and greater prior comorbidity diminished the beneficial effects of transplantation.
274 citations
TL;DR: FOG should be viewed as a highly important symptom with regard to QoL of PD patients beyond its effect on gait and mobility and special attention should be given to FOG in the treatment of patients with PD.
Abstract: The aim of this study was to examine the association between freezing of gait (FOG) and quality of life (QoL) in patients with Parkinson's disease (PD). PD patients (n = 118) completed the PDQ-39 (QoL) and FOG-Q questionnaires. Disease severity was assessed by the Hoehn and Yahr (H&Y) staging and the Unified Parkinson's Disease Rating Scale (UPDRS). The relations between those parameters were assessed using regression models. 66 men and 52 women (mean age 65.8 ± 10.2 years, UPDRS total score 48.4 ± 17.1, disease duration 8.5 ± 5.8 years, H&Y stage 2.7 ± 0.8) participated. FOG severity had a significant effect on QoL (P < 0.0015), accounting for disease severity assessed by UPDRS. Specifically, FOG severity was correlated with all the dimensions of the PDQ-39 except for stigma and social support, as follows: with mobility, bodily discomfort, activity of daily living (ADL) (P < 0.005 in all), with emotional, communication, and cognition (P < 0.05 in all). FOG severity (FOG-Q) was also found to affect a modified PDQ total score, without the mobility aspect (P = 0.0081). FOG should be viewed as a highly important symptom with regard to QoL of PD patients beyond its effect on gait and mobility. On the basis of the present results, special attention should be given to FOG in the treatment of patients with PD. © 2007 Movement Disorder Society
274 citations
Book•
01 Jul 1991
TL;DR: Quality of Life in the Treatment Process in Pediatric Oncology, Quality-of-Life Research in the European Palliative Care Setting, and Uses (and Some Possible Abuses) of Quality- of-Life Measures.
Abstract: Perspectives on Quality of Life and the Global Cancer Problem. Measuring Functioning, Well-Being, and Other Generic Health Concepts. Measuring Effects of Cancer on Quality of Life. Prediction of Psychosocial Distress in Patients with. N of 1 Randomized Controlled Trials for Investigation of Quality of Life in Cancer. Quality of Life in the Treatment Process in Pediatric Oncology: An Approach to Measurement. A Practical Guide for Selecting Quality-of-Life Measures in Clinical Trials and Practice. Incorporation of Quality of Life Assessment into Clinical Trials. Statistical Analysis of Trials Assessing Quality of Life. Economic Evaluations of Cancer Care-Incorporating Quality of Life Issues. Uses (and Some Possible Abuses) of Quality-of-Life Measures. Cancer Patients' Unmet Support Needs as a Quality-of-Life Indicator. The Spitzer Quality-of-Life Index: Its Performance as a Measure. The EORTC Core Quality-of-Life Questionnaire: Interim Results of an International Field Study. Quality of Life in Breast Cancer. Women's Sexuality Following Breast Cancer. Methodological Issues in Anti-Emetic Studies. Anticipatory Nausea and Vomiting Side Effects Experienced by Cancer Patients Undergoing Chemotherapy Treatment. Selective 5-Ht, Receptor Antagonists: A Novel Class of Antiemetics. Pain and Quality of Life: Theoretical Aspects. Pain Assessment in Cancer. Clinical Trials in Pain Control. Quality-of-Life Research in the European Palliative Care Setting. Quality-of-Life Research in Hospice Care.
274 citations
TL;DR: Comparison of the quality of life of patients with endometrial cancer undergoing surgical staging via laparoscopy versus laparotomy provides modest support for the QoL advantage of using laparoscope to stage patients with early endometricrial cancer.
Abstract: Purpose The study's objective was to compare the quality of life (QoL) of patients with endometrial cancer undergoing surgical staging via laparoscopy versus laparotomy. Patients and Methods The first 802 eligible patients (laparoscopy, n = 535; laparotomy, n = 267) participated in the QoL study in a Gynecologic Oncology Group (GOG) randomized trial of laparoscopy versus laparotomy (GOG 2222). Patients completed QoL assessments at baseline; at 1, 3, and 6 weeks; and at 6 months postsurgery. Results In an intent-to-treat analysis, laparoscopy patients reported significantly higher Functional Assessment of Cancer Therapy–General (FACT-G) scores (P = .001), better physical functioning (P = .006), better body image (BI; P < .001), less pain (P < .001) and its interference with QoL (P < .001), and an earlier resumption of normal activities (P = .003) and return to work (P = .04) over the 6-week postsurgery period, as compared with laparotomy patients. However, the differences in BI and return to work between g...
274 citations
TL;DR: Exercise-induced QOL improvements were dose dependent and independent of weight change, and higher doses of exercise were associated with larger improvements in mental and physical aspects of QOL.
Abstract: Methods: The effect of 50%, 100%, and 150% of the physical activity recommendation on QOL was examined in a 6-month randomized controlled trial. Participants were 430 sedentary postmenopausal women (body mass index range, 25.0-43.0 [calculated as weight in kilograms divided by height in meters squared]) with elevated systolic blood pressure randomized to a nonexercise control group (n=92) or 1 of 3 exercise groups: exercise energy expenditure of 4 (n=147), 8 (n=96), or 12 (n=95) kilocalories per kilogram of body weight per week. Eight aspects of physical and mental QOL were measured at baseline and month 6 with the use of the Medical Outcomes Study 36-Item Short Form Health Survey. Results: Change in all mental and physical aspects of QOL, except bodily pain, was dose dependent (trend analyses were significant, and exercise dose was a significant predictor of QOL change; P.05). Higher doses of exercise were associated with larger improvements in mental and physical aspects of QOL. Controlling for weight change did not attenuate the exercise-QOL association. Conclusion: Exercise-induced QOL improvements were dose dependent and independent of weight change. Trial Registration: clinicaltrials.gov Identifier: NCT00011193
273 citations