Topic
Raman spectroscopy
About: Raman spectroscopy is a research topic. Over the lifetime, 122605 publications have been published within this topic receiving 2891083 citations. The topic is also known as: Raman Spectrum Analysis & spectrum Analysis, Raman.
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Papers
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TL;DR: This is believed to be the first report showing bacterial discrimination using SERS, and the resultant ordination plots and dendrograms showed correct groupings for these organisms, including discrimination to strain level for a sample group of Escherichia coli.
Abstract: Raman spectroscopy has recently been shown to be a potentially powerful whole-organism fingerprinting technique and is attracting interest within microbial systematics for the rapid identification ...
622 citations
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TL;DR: In this article, the small signal Raman gain in a single-mode glass waveguide amplifier has been measured directly and the measured gain is in good agreement with that calculated from the Raman cross section.
Abstract: The small signal Raman gain in a single‐mode glass waveguide amplifier has been measured directly. The measured gain is in good agreement with that calculated from the Raman cross section. The cross section was determined by a comparison of the spontaneous Raman scattering of fused quartz and benzene.
620 citations
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TL;DR: Noninvasive deep-tissue molecular images in a living subject with the use of Raman spectroscopy are presented and the imaging modality reported here holds significant potential as a strategy for biomedical imaging of living subjects.
Abstract: Molecular imaging of living subjects continues to rapidly evolve with bioluminescence and fluorescence strategies, in particular being frequently used for small-animal models. This article presents noninvasive deep-tissue molecular images in a living subject with the use of Raman spectroscopy. We describe a strategy for small-animal optical imaging based on Raman spectroscopy and Raman nanoparticles. Surface-enhanced Raman scattering nanoparticles and single-wall carbon nanotubes were used to demonstrate whole-body Raman imaging, nanoparticle pharmacokinetics, multiplexing, and in vivo tumor targeting, using an imaging system adapted for small-animal Raman imaging. The imaging modality reported here holds significant potential as a strategy for biomedical imaging of living subjects.
618 citations
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TL;DR: In this article, a mixture of hydrocarbon and hydrogen gases was passed through a heated reaction chamber in which a hot tungsten filament was held near the substrates, and the deposit was identified by reflection electron diffraction and Raman spectroscopy.
Abstract: Microcrystals of diamond were grown on non-diamond substrates including silicon, molybdenum and silica, as well as on diamond by chemical vapour deposition. Deposition was carried out by passing a mixture of hydrocarbon and hydrogen gases through a heated reaction chamber in which a hot tungsten filament was held near the substrates. The deposit was identified by reflection electron diffraction and Raman spectroscopy. The effects of experimental conditions on the growth features were studied.
618 citations
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TL;DR: This surface enhanced Raman scattering (SERS) geometry offers large surface enhancements for molecules adsorbed onto planar substrates and could be quite useful for determining chemical information for poor Raman scatterers from assays on 2-D substrates.
Abstract: Surface enhanced Raman scattering (SERS) spectra of 4-mercaptobenzoic acid (4-MBA) self-assembled monolayers (SAMs) on gold substrates is presented for SAMs onto which gold nanoparticles of various shapes have been electrostatically immobilized. SERS spectra of 4-MBA SAMs are enhanced in the presence of immobilized gold nanocrystals by a factor of 107−109 relative to 4-MBA in solution. Large enhancement factors are a likely result of plasmon coupling between the nanoparticles (localized surface plasmon) and the smooth gold substrate (surface plasmon polariton), creating large localized electromagnetic fields at their interface, where 4-MBA molecules reside in this sandwich architecture. Moreover, enhancement factors depend on nanoparticle shape and vary by a factor of 102. This SERS geometry offers large surface enhancements for molecules adsorbed onto planar substrates and could be quite useful for determining chemical information for poor Raman scatterers from assays on 2-D substrates.
617 citations