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Random effects model

About: Random effects model is a research topic. Over the lifetime, 8388 publications have been published within this topic receiving 438823 citations. The topic is also known as: random effects & random effect.


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Journal ArticleDOI
Philip Hougaard1
TL;DR: A frailty model is a random effects model for time variables, where the random effect (the frailty) has a multiplicative effect on the hazard.
Abstract: A frailty model is a random effects model for time variables, where the random effect (the frailty) has a multiplicative effect on the hazard. It can be used for univariate (independent) failure times, i.e. to describe the influence of unobserved covariates in a proportional hazards model. More interesting, however, is to consider multivariate (dependent) failure times generated as conditionally independent times given the frailty. This approach can be used both for survival times for individuals, like twins or family members, and for repeated events for the same individual. The standard assumption is to use a gamma distribution for the frailty, but this is a restriction that implies that the dependence is most important for late events. More generally, the distribution can be stable, inverse Gaussian, or follow a power variance function exponential family. Theoretically, large differences are seen between the choices. In practice, using the largest model makes it possible to allow for more general dependence structures, without making the formulas too complicated.

541 citations

Journal ArticleDOI
TL;DR: The study shows that inter-subject variability plays a prominent role in the relatively low sensitivity and reliability of group studies and focuses on the notion of reproducibility by bootstrapping.

541 citations

Journal ArticleDOI
TL;DR: It is described how a full Bayesian analysis can deal with unresolved issues, such as the choice between fixed- and random-effects models, the choice of population distribution in a random- effects analysis, the treatment of small studies and extreme results, and incorporation of study-specific covariates.
Abstract: Current methods for meta-analysis still leave a number of unresolved issues, such as the choice between fixed- and random-effects models, the choice of population distribution in a random-effects analysis, the treatment of small studies and extreme results, and incorporation of study-specific covariates. We describe how a full Bayesian analysis can deal with these and other issues in a natural way, illustrated by a recent published example that displays a number of problems. Such analyses are now generally available using the BUGS implementation of Markov chain Monte Carlo numerical integration techniques. Appropriate proper prior distributions are derived, and sensitivity analysis to a variety of prior assumptions carried out. Current methods are briefly summarized and compared to the full Bayes analysis.

535 citations

Journal ArticleDOI
TL;DR: In this article, a hierarchical analysis of variance (ANOVA) is proposed to automatically give the correct ANOVA comparisons even in complex scenarios, where inferences for all means and variances are performed under a model with a separate batch of effects for each row of the ANOVA table.
Abstract: Analysis of variance (ANOVA) is an extremely important method in exploratory and confirmatory data analysis. Unfortunately, in complex problems (e.g., split-plot designs), it is not always easy to set up an appropriate ANOVA. We propose a hierarchical analysis that automatically gives the correct ANOVA comparisons even in complex scenarios. The inferences for all means and variances are performed under a model with a separate batch of effects for each row of the ANOVA table. We connect to classical ANOVA by working with finite-sample variance components: fixed and random effects models are characterized by inferences about existing levels of a factor and new levels, respectively. We also introduce a new graphical display showing inferences about the standard deviations of each batch of effects. We illustrate with two examples from our applied data analysis, first illustrating the usefulness of our hierarchical computations and displays, and second showing how the ideas of ANOVA are helpful in understanding a previously fit hierarchical model.

533 citations

Journal ArticleDOI
TL;DR: TMB is an open source R package that enables quick implementation of complex nonlinear random effect (latent variable) models in a manner similar to the established AD Model Builder package, and is designed to be fast for problems with many random effects and parameters.
Abstract: TMB is an open source R package that enables quick implementation of complex nonlinear random effects (latent variable) models in a manner similar to the established AD Model Builder package (ADMB, http://admb-project.org/; Fournier et al. 2011). In addition, it offers easy access to parallel computations. The user defines the joint likelihood for the data and the random effects as a C++ template function, while all the other operations are done in R; e.g., reading in the data. The package evaluates and maximizes the Laplace approximation of the marginal likelihood where the random effects are automatically integrated out. This approximation, and its derivatives, are obtained using automatic differentiation (up to order three) of the joint likelihood. The computations are designed to be fast for problems with many random effects (≈ 106 ) and parameters (≈ 103 ). Computation times using ADMB and TMB are compared on a suite of examples ranging from simple models to large spatial models where the random effects are a Gaussian random field. Speedups ranging from 1.5 to about 100 are obtained with increasing gains for large problems. The package and examples are available at http://tmb-project.org/.

533 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20241
2023198
2022433
2021409
2020380
2019404