Topic
Rapid eye movement sleep
About: Rapid eye movement sleep is a research topic. Over the lifetime, 3740 publications have been published within this topic receiving 183415 citations. The topic is also known as: REM sleep & REMS.
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TL;DR: Comparisons of the present results with previously reported changes in hypothalamic GHRH mRNA suggest that periods of deep nonrapid eye movement sleep (first portion of the light period and recovery sleep after SD) are associated with intense hypothalamicGHRH release.
Abstract: Previous reports indicate that hypothalamic growth hormone-releasing hormone (GHRH) promotes sleep and is involved in sleep regulation. The aim of our experiments was to determine whether the GHRH and somatostatin contents of the rat hypothalamus have diurnal variations and whether they are altered by sleep deprivation (SD). Hypothalamic samples were collected at 10 time points during the 24-h light-dark cycle. SD started at light onset. Hypothalamic samples were obtained after 4 and 8 h of SD and after 1 and 2 h of recovery following 8 h of SD. The peptides were determined by means of radioimmunoassay. GHRH displayed significant diurnal variations with low levels in the morning (a transient rise occurred at 1 h after light onset), gradual increases in the afternoon (peak at the end of the light period and beginning of the dark period), and decreases at night. SD induced significant GHRH depletion, which persisted during recovery. The afternoon rise was delayed, and the nocturnal decline of somatostatin was more rapid than the changes in GHRH. Although the patterns of the diurnal variations in GHRH and somatostatin were similar, there was no significant correlation between them. SD did not alter somatostatin significantly. Comparisons of the present results with previously reported changes in hypothalamic GHRH mRNA suggest that periods of deep nonrapid eye movement sleep (first portion of the light period and recovery sleep after SD) are associated with intense hypothalamic GHRH release.
62 citations
TL;DR: The dopamine D1 receptor agonist, SKF 38393, and the D1 antagonist, SCH 23390, were studied for their effects on sleep in the rat and it is suggested that D1 receptors are involved in the regulation of the REM sleep process.
62 citations
TL;DR: It is demonstrated that inactivating CNA can produce a relatively selective suppression of REM, and the possible role that spontaneous activity in CNA may play in REM initiation and/or maintenance is discussed.
62 citations
TL;DR: It is concluded that circadian phase and time awake have a substantial impact on short and stimulating planning tasks, which are related to the prefrontal cortex, and on sequence learning that requires activation of striatal brain regions.
Abstract: Variations in waking neurobehavioral or cognitive functioning are closely linked to endogenous 24-h rhythm (circadian pacemaker) and time awake. We summarize studies in which the contribution of the circadian pacemaker and time awake on neurobehavioral function was investigated. Stable and high levels of attention and vigilance can only be maintained when the circadian timing system opposes the wake-dependent deterioration of alertness and performance. Planning performance in a maze tracing task was also affected by time awake, whereas circadian modulation was less pronounced. Additional to circadian phase position and the level of sleep pressure, rapid eye movement sleep may play a role in acquiring specific procedural skills in a sequence learning task. We conclude that circadian phase and time awake have a substantial impact on short and stimulating planning tasks, which are related to the prefrontal cortex, and on sequence learning that requires activation of striatal brain regions.
62 citations
TL;DR: Results show that IL1-induced sleep and fever responses can be separated, and somnogenic sites of action for IL1 and muramyl peptides remain unknown.
62 citations