Topic
Rapid eye movement sleep
About: Rapid eye movement sleep is a research topic. Over the lifetime, 3740 publications have been published within this topic receiving 183415 citations. The topic is also known as: REM sleep & REMS.
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TL;DR: The rising REM sleep propensity, as reflected by the increase of interventions within and across RD nights, and the moderate REM sleep rebound during recovery can be accounted for by a compensatory response that serves REM sleep homeostasis.
Abstract: To investigate rapid eye movement (REM) sleep regulation, eight healthy young men were deprived of REM sleep for three consecutive nights. In a three-night control sleep deprivation (CD) session 2 wk later, the subjects were repeatedly awakened from non-REM sleep in an attempt to match the awakenings during the REM sleep deprivation (RD) nights. During the RD nights the number of sleep interruptions required to prevent REM sleep increased within and across consecutive nights. REM sleep was reduced to 9.2% of baseline (CD nights: 80.7%) and rose to 140.1% in the first recovery night. RD gave rise to changes in the EEG power spectra of REM sleep. Power in the 8.25- to 11-Hz range was reduced in the first recovery night, an effect that gradually subsided but was still present in the third recovery night. The rising REM sleep propensity, as reflected by the increase of interventions within and across RD nights, and the moderate REM sleep rebound during recovery can be accounted for by a compensatory response that serves REM sleep homeostasis. The changes in the electroencephalogram power spectra, which were observed during enhanced REM sleep propensity, may be a sign of an altered quality of REM sleep.
124 citations
Journal Article•
TL;DR: Experimental evidence shows that during drowsiness, disfacilitation in thalamic and cortical neurons (by partial removal of influences from mesopontine, posterior hypothalamic, and basal forebrain activating systems) may coexist with active hypnogenic mechanisms.
Abstract: Most brainstem, thalamic, and cortical cellular types undergo similar processes during rapid eye movement (REM) sleep and wakefulness, and both these brain-activated behavioral states are opposed to the resting EEG-synchronized sleep. Experimental evidence shows that during drowsiness, disfacilitation in thalamic and cortical neurons (by partial removal of influences from mesopontine, posterior hypothalamic, and basal forebrain activating systems) may coexist with active hypnogenic mechanisms. The idea of an active induction of sleep, however, still lacks firm support at the cellular level. The generation of REM sleep signs is probably caused, at least partially, by the disinhibition of mesopontine cholinergic cells, the executive elements of tonic and phasic events during dreaming sleep, following cessation of firing of inhibitory serotonergic dorsal raphe neurons.
124 citations
TL;DR: In this paper, a 1-mg oral dose of SR 46349B, a novel 5-HT2 antagonist, was administered three hours before bedtime to investigate the effect on the sleep EEG.
124 citations
TL;DR: Findings highlight the role of subjective and REM sleep measures as correlates of short-term psychotherapy treatment response in major depressive disorder and suggest disturbed sleep may be a physiological indicator of increased limbic and brain stem arousal.
124 citations
TL;DR: There is little, if any, contribution of these inhibitory amino acids to the depression of XII motoneurons during the carbachol-induced, REM sleep-like postural and respiratory depression; mechanisms other than fast synaptic inhibition must be involved.
124 citations