Topic
Reagent
About: Reagent is a research topic. Over the lifetime, 60091 publications have been published within this topic receiving 1234928 citations. The topic is also known as: reagens.
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158 citations
TL;DR: Ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonate (SBD-F) was newly synthesized as a fluorogenic reagent for thiol compounds and its reactivity to glutathione is superior to its 7-chloro analog, SBD-Cl.
158 citations
TL;DR: The mild reaction conditions allowed the first ethynylation reactions of linear keto, cyano and nitro esters in high yields to give all-carbon quaternary centers or non-natural amino acids after selective reduction of the nitro group.
Abstract: Hot alkyne! The in situ generation of Ethynyl-1,2-BenziodoXol-3(1H)-one (EBX) from the corresponding silyl protected reagent using TBAF is reported. EBX displayed exceptional acetylene transfer ability to stabilized enolates, even at –78 °C. The mild reaction conditions allowed the first ethynylation reactions of linear keto, cyano and nitro esters in high yields to give all-carbon quaternary centers or non-natural amino acids after selective reduction of the nitro group.
157 citations
TL;DR: An amine-N-oxide-ligated palladium complex, in conjunction with a silver cocatalyst, catalyzes imidation of arenes by the reagent N-fluorobenzenesulfonimide, requiring no coordinating directing group on the substrate, and giving synthetically useful yields with only 1 equiv of arene.
Abstract: An amine-N-oxide-ligated palladium complex, in conjunction with a silver cocatalyst, catalyzes imidation of arenes by the reagent N-fluorobenzenesulfonimide. The reaction enables imidation of a variety of arenes at or below room temperature, requires no coordinating directing group on the substrate, and gives synthetically useful yields with only 1 equiv of arene. Mechanistic data implicate an unusual mechanism devoid of commonly invoked organometallic intermediates: oxidation of the Pd catalyst occurs as the turnover-limiting step, while C–H bond functionalization occurs subsequently at a high oxidation state of the catalyst.
157 citations
TL;DR: Oxidative biaryl coupling reaction of phenol ether derivatives with the hypervalent iodine reagent, phenyliodine(III) bis(trifluoroacetate) (PIFA), in the presence of BF3·Et2O gave a variety of substituted biphenyl and binaphthyl compounds in high yields.
157 citations