Topic
Reagent
About: Reagent is a research topic. Over the lifetime, 60091 publications have been published within this topic receiving 1234928 citations. The topic is also known as: reagens.
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TL;DR: A sequential chemical extraction method for the determination of the geochemical fractionation of Am, Pu, and U was evaluated rigorously on a single marine sediment standard (IAEA -135) as discussed by the authors.
120 citations
TL;DR: The results indicate the ability of this method for synthesis of new reagent in nano size and improve quality of in situ chemical oxidation.
120 citations
TL;DR: In this article, a remotely controlled procedure was developed for the routine synthesis of [CARONYL-11 C]WAY-100635, a radioligand for the study of 5-HT 1A receptors in human brain with positron emission tomography (PET).
Abstract: WAY-100635 [N-(2-(1-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl))-N-(2-pyridyl)-cyclohexanecarboxamide], when labelled in its carbonyl position with carbon-11 (t 1/2 = 20.4 min), is an effective radioligand for the study of 5-HT 1A receptors in human brain with positron emission tomography (PET). A simple remotely-controlled procedure was developed for the routine synthesis of [carbonyl- 11 C]WAY-100635. Thus, cyclohexylmagnesium chloride is coated onto the inner surface of a narrow polypropylene tube. Cyclotron-produced [ 11 C]carbon dioxide is passed into the tube in a nitrogen stream. A solution of thionyl chloride in tetrahydrofuran is then passed through the tube to convert the trapped radioactive adduct into [carbonyl- 11 C]cyclohexanecarbonyl chloride and to release this labelling agent into a vial containing 1-(2-methoxyphenyl)-4-(2-(2-pyridylamino)ethyl)piperazine plus triethylamine. The vial is sealed and heated to 70'C for 5 min. [carbonyl 11 C]WAY-100635 is isolated by sample-enrichment and reverse phasc HPLC and formulated for human intravenous injection by evaporation of solvent and dissolution in 'saline for injection'. The novel use of the immobilized Grignard reagent has the advantages that only small quantifies of all reagents are required so simplifying product purification. Moreover, the procedure was readily adapted for operation in a shielded hot-cell with remote control for radiation safety. The remotely-controlled radiosynthesis takes 45 min and gives high radioactivities (2.96-5.92 GBq) of formulated [carbonyl- 11 C]WAY-100635 in > 99% radiochemical purity and high specific radioactivity (average, 192 GBq/μmol).
119 citations
TL;DR: In this paper, the extraction of rhodium, platinum and palladium with Cyanex 921 from aqueous hydrochloric acid media has been examined in the absence and in the presence of tin(II) chloride.
119 citations
TL;DR: The sonochemical degradation rate of Methylene Blue is markedly increased in the presence of Fe(Ill), a rather inexpensive reagent for the application of sonochemistry to wastewater treatment, where both reactants (Fe(ll) and H2O2) are sonochemically synthesized.
Abstract: The sonochemical degradation rate of Methylene Blue (MB) is markedly increased in the presence of Fe(III), a rather inexpensive reagent for the application of sonochemistry to wastewater treatment....
119 citations