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Receptive field

About: Receptive field is a research topic. Over the lifetime, 8537 publications have been published within this topic receiving 596428 citations.


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TL;DR: By behaviorally training adult owl monkeys to discriminate the temporal features of a tactile stimulus, distributed spatial and temporal response properties of cortical neurons are altered.
Abstract: 1. Temporal response characteristics of neurons were sampled in fine spatial grain throughout the hand representations in cortical areas 3a and 3b in adult owl monkeys. These monkeys had been trained to detect small differences in tactile stimulus frequencies in the range of 20-30 Hz. Stimuli were presented to an invariant, restricted spot on a single digit. 2. The absolute numbers of cortical locations and the cortical area over which neurons showed entrained frequency-following responses to behaviorally important stimuli were significantly greater when stimulation was applied to the trained skin, as compared with stimulation on an adjacent control digit, or at corresponding skin sites in passively stimulated control animals. 3. Representational maps defined with sinusoidal stimuli were not identical to maps defined with just-visible tapping stimuli. Receptive-field/frequency-following response site mismatches were recorded in every trained monkey. Mismatches were less frequently recorded in the representations of control skin surfaces. 4. At cortical locations with entrained responses, neither the absolute firing rates of neurons nor the degree of the entrainment of the response were correlated with behavioral discrimination performance. 5. All area 3b cortical locations with entrained responses evoked by stimulation at trained or untrained skin sites were combined to create population peristimulus time and cycle histograms. In all cases, stimulation of the trained skin resulted in 1) larger-amplitude responses, 2) peak responses earlier in the stimulus cycle, and 3) temporally sharper responses, than did stimulation applied to control skin sites. 6. The sharpening of the response of cortical area 3b neurons relative to the period of the stimulus could be accounted for by a large subpopulation of neurons that had highly coherent responses. 7. Analysis of cycle histograms for area 3b neuron responses revealed that the decreased variance in the representation of each stimulus cycle could account for behaviorally measured frequency discrimination performance. A strong correlation between these temporal response distributions and the discriminative performances for stimuli applied at all studied skin surfaces was even stronger (r = 0.98) if only the rising phases of cycle histogram were considered in the analysis. 8. The responses of neurons in area 3a could not account for measured differences in frequency discrimination performance. 9. These representational changes did not occur in monkeys that were stimulated on the same schedule but were performing an auditory discrimination task during skin stimulation. 10. It is concluded that by behaviorally training adult owl monkeys to discriminate the temporal features of a tactile stimulus, distributed spatial and temporal response properties of cortical neurons are altered.(ABSTRACT TRUNCATED AT 400 WORDS)

313 citations

Journal ArticleDOI
TL;DR: Microelectrode recording techniques were used to investigate the projection of the visual field into the lateral geniculate nucleus of Macaca mulatta, and two families of surfaces representing visual directions of constant azimuth and elevation are described.
Abstract: Microelectrode recording techniques were used to investigate the projection of the visual field into the lateral geniculate nucleus (LGN) of Macaca mulatta. The data were used to construct charts plotting visual direction, designated in terms of azimuth and elevation, onto sections of the nucleus cut in coronal, sagittal and horizontal Horsley-Clarke planes. The projection of the horizontal meridian divides the LGN along its plane of symmetry into a medial-superior half having negative elevations and a lateral-inferior half having positive elevations. Elevations become more positive or negative with distance from this plane. Azimuths closest to the vertical meridian are located posteriorly, while the most peripheral azimuths are found at the anterior pole. Two families of surfaces representing visual directions of constant azimuth and elevation are described. Visual field zones of increasing eccentricity are represented serially along the posterior-anterior axis of the LGN, with the foveal area restricted to the posterior pole and the monocular crescent projecting to the anterior pole. The mapping is completely continuous across the horizontal meridian. The edges of the stacked cell laminae exposed around the periphery of the LGN form an oval band which receives the projection of the perimeter of the contralateral hemifield. The vertical meridian is represented by the posterior two-thirds of this band, while the periphery of the hemifield projects to the anterior third. The central visual field out to the optic disc is represented by six cell layers, while the rest of the binocular field projects to four layers only (2 parvocellular and 2 magnocellular). The monocular crescent is represented by one parvocellular and one magnocellular layer. Features associated with the projection column of the optic disc are integrated into the transition from six to four layers. Details of the receptive field topography in the vicinity of the optic disc discontinuities indicate that these gaps are produced by intralaminar mechanisms. The magnification factor (mm3/steradian) increases monotonically from peripheral visual fields to the foveal center, varying over a range of three decades. This range is intermediate between those derived from data reported in the literature for the retina and the striate cortex. The ratio of LGN magnifications at any two angular eccentricities is a power function, with an exponent of 1.34, of the corresponding ratio of retinal ganglion cell densities. Similarly, the ratio of cortical magnifications (mm2/steradian) at any two eccentricites is a power function, with an exponent of 1.35, of the corresponding ratio of LGN magnifications.

313 citations

Journal ArticleDOI
TL;DR: The findings suggest that nearby inhibitory neurons are more tightly synchronized than excitatory ones and account for much of the correlated discharges commonly observed in undifferentiated cortical networks.
Abstract: Neurophysiological recordings have revealed that the discharges of nearby cortical cells are positively correlated in time scales that range from millisecond synchronization of action potentials to much slower firing rate co-variations, evident in rates averaged over hundreds of milliseconds The presence of correlated firing can offer insights into the patterns of connectivity between neurons; however, few models of population coding have taken account of the neuronal diversity present in cerebral cortex, notably a distinction between inhibitory and excitatory cells We addressed this question in the monkey dorsolateral prefrontal cortex by recording neuronal activity from multiple micro-electrodes, typically spaced 02-03 mm apart Putative excitatory and inhibitory neurons were distinguished based on their action potential waveform and baseline discharge rate We tested each pair of simultaneously recorded neurons for presence of significant cross-correlation peaks and measured the correlation of their averaged firing rates in successive trials When observed, cross-correlation peaks were centered at time 0, indicating synchronous firing consistent with two neurons receiving common input Discharges in pairs of putative inhibitory interneurons were found to be significantly more strongly correlated than in pairs of putative excitatory cells The degree of correlated firing was also higher for neurons with similar spatial receptive fields and neurons active in the same epochs of the behavioral task These factors were important in predicting the strength of both short time scale (<5 ms) correlations and of trial-to-trial discharge rate covariations Correlated firing was only marginally accounted for by motor and behavioral variations between trials Our findings suggest that nearby inhibitory neurons are more tightly synchronized than excitatory ones and account for much of the correlated discharges commonly observed in undifferentiated cortical networks In contrast, the discharge of pyramidal neurons, the sole projection cells of the cerebral cortex, appears largely independent, suggesting that correlated firing may be a property confined within local circuits and only to a lesser degree propagated to distant cortical areas and modules

313 citations

Journal ArticleDOI
TL;DR: The hypothesis that catecholamines are required for the maintenance of visual cortical plasticity during the critical period is supported, as the overwhelming majority of cortical neurons in 6‐OHDA‐treated kittens remained normal in receptive field properties after a period of monocular deprivation.
Abstract: The results of single unit recordings from Area 17 of monocularly deprived kittens were compared with similar ones from littermates who had been monocularly lid-sutured for the same period of time, but who had in addition been given intraventricular injections of 6-hydroxydopamine (6-OHDA) to deplete brain catecholamines. This visual cortices of all catecholamine-depleted kittens showed high proportions of binocular neurons, in contrast to the control group, a majority of whose visual cortical neurons were driven exclusively by the non-deprived eye. Preservation of binocularity in 6-OHDA-treated kittens was dose-related. Even after a 1 to 2-week period of lidsuture which reduced binocularity to 20% in controls, normal proportions of binocular neurons (greater than 75%) were preserved if the cumulative dose had been 10 mg 6-OHDA or more. The density of single neurons sampled from electrode tracks through the cortex of drug-treated kittens was high and did not differ significantly from controls. Neurons were isolated every 100 micron on the average. There was some indication that the drug's effect in preventing an ocular dominance shift disappears by six weeks following cessation of 6-OHDA treatment. This reversal of the physiological effects in cortex is preceded by recovery from the behavioral manifestations of 6-OHDA treatments. Binocularity was only slightly increased in a kitten who received large doses of 6-OHDA after a period of monocular deprivation. This observation, together with control recordings from normal kittens and adults treated with 6-OHDA, indicates that the direct effects of 6-OHDA on cortical neurons' response properties play a minor role in comparison to its effects in reducing the sensitivity of the cortex to monocular deprivation. The overwhelming majority of cortical neurons in 6-OHDA-treated kittens remained normal in receptive field properties after a period of monocular deprivation. These data support the hypothesis that catecholamines are required for the maintenance of visual cortical plasticity during the critical period.

312 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023137
2022310
2021168
2020157
2019176
2018193