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Receptive field
About: Receptive field is a research topic. Over the lifetime, 8537 publications have been published within this topic receiving 596428 citations.
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TL;DR: It is shown that combined CRF + nCRF stimulation increases the sparseness, reliability, and precision of spiking and membrane potential responses in classical regular spiking neurons of cat primary visual cortex, suggesting that network interactions among neuronal subtypes ultimately sharpen recurrent excitation, producing specific and reliable visual responses.
265 citations
TL;DR: In this paper, the authors found that exposure to pulsed white noise at moderate intensity during P9-P28 resulted in a disrupted tonotopicity and degraded frequency-response selectivity for neurons in the primary auditory cortex.
Abstract: In the primary auditory cortex (AI), the development of tone frequency selectivity and tonotopic organization is influenced by patterns of neural activity. Introduction of synchronous inputs into the auditory pathway achieved by exposing rat pups to pulsed white noise at a moderate intensity during P9–P28 resulted in a disrupted tonotopicity and degraded frequency-response selectivity for neurons in the adult AI. The latter was manifested by broader-than-normal tuning curves, multipeaks, and discontinuous, tone-evoked responses within AI-receptive fields. These effects correlated with the severe impairment of normal, developmental sharpening, and refinement of receptive fields and tonotopicity. In addition, paradoxically weaker than normal temporal correlations between the discharges of nearby AI neurons were recorded in exposed rats. In contrast, noise exposure of rats older than P30 did not cause significant change of auditory cortical maps. Thus, patterned auditory inputs appear to play a crucial role in shaping neuronal processing/decoding circuits in the primary auditory cortex during a critical period.
265 citations
TL;DR: The neurophysiological results demonstrated changes at the single neuron level which paralleled the degree of the behavioral changes: in animals with very poor acuity in the deprived or deviate eye (the form deprived and one esotropic animal), only a small number of neurons were driven from the operated eye; in one esotrope and the exotropic animal, which had good acuity, many neurons received an input from that eye, but only asmall number of these were binocular.
265 citations
TL;DR: The functional role of the layer 6 to layer 4 projection is determined by reversible inactivation of layer 6 using the inhibitory transmitter γ-aminobutyric acid (GABA) and cells in layer 4 lost end-inhibition.
Abstract: To understand the mechanisms by which the receptive field properties of visual cortical cells are generated, one must consider both the thalamic input to the cortex and the intrinsic cortical connections In the cat striate cortex, layer 4 is the main recipient of input from the lateral geniculate nucleus, yet the cells in that layer possess several receptive field properties that are distinct from the geniculate input, including orientation specificity, binocularity, directionality and end-inhibition, the last of which allows cells to respond to edges of a restricted length These properties could be generated by connections within the layer, by its input from the claustrum or by the massive projection that layer 4 receives from layer 6 In the present study, we attempted to determine the functional role of the layer 6 to layer 4 projection by reversible inactivation of layer 6 using the inhibitory transmitter gamma-aminobutyric acid (GABA) After inactivating layer 6, cells in layer 4 lost end-inhibition Cells in layer 2 + 3, which receive their principal input from layer 4, were similarly affected The elimination of end-inhibition was specific, other receptive field properties, such as direction selectivity or orientation specificity, remaining intact
265 citations
TL;DR: Evidence is presented that one effect of rearing cats with visual deprivation is the selective elimination from the LGNd of Y-cells, and the remaining neurons appear to be functionally normal.
Abstract: cATs REARED under various conditions of visual deprivation are deficient in their subsequent performance of certain visual tasks (6, 19). Wiesel and Hubel (15-17, 25-28) have sought the physiological basis of these effects by comparing receptivefield properties of single visual neurons of normhlly reared cats to those of visually deprived cats. Their consistent finding (17, 26-28), confirmed by others (7), is that cells of the striate cortex develop permanently abnormal receptive-field properties during deprivation rearing. In a preliminary study, Wiesel and Hubel (25) observed that cells of the dorsal lateral geniculate nucleus (LGNd) in visually deprived cats have essentially normal receptive fields despite the loss of many large cells in this nucleus. These findings have been subtantially confirmed (11, 24). The present studv which follows note the a series presence of of t recent wo funct papers ionallv distinct types of cell in the cat’s retina and LGNd: the X-cells (3, 13) (type II (5, 21) or sustained cells (2)) and the Y-cells (3, 13) (type I (5, 21) or transient cells (2)). This paper presents evidence that one effect of rearing cats with visual deprivation (achieved by neonatal eyelid suture) is the selective elimination from the LGNd of Y-cells. The remaining neurons appear to be functionally normal.
264 citations