Receptor

TL;DR: The fas gene plays an essential role in activation-induced cell death in mature T lymphocytes, but not in the negative selection of immature cells in the thymus in MRL-lpr/lpr and MRL+/+ strains.

TL;DR: EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function, and EphrinB activation of EphB promotes an association of E phB with NMDA receptors that may be critical for synapse development or function.

TL;DR: In vivo studies show that inhibition of γ-secretase has the expected benefit of reducing Aβ in a murine model of Alzheimer disease but has potentially undesirable biological effects as well, most likely because of the inhibition of Notch processing.

TL;DR: The expressed AT2 receptor mediated angiotensin II-induced inhibition of protein tyrosine phosphatase, an action that was dependent on a pertussis toxin-sensitive G-protein-coupled mechanism in COS-7 cells, and suggested novel functional roles of the renin-angiotens in system in cross-talk with phosphotyrosine signaling by modulating protein phosphotYrosine levels.

TL;DR: It is found that a 1000-fold excess of the heterologous ligand is needed to reduce binding to the high-affinity receptor by 50%, but that the same concentrations of BDNF and NGF similarly reduce the binding of either ligand to the low-Affinity receptor.