Topic
Receptor
About: Receptor is a research topic. Over the lifetime, 159318 publications have been published within this topic receiving 8299881 citations.
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TL;DR: Understanding precisely how the heart can recognize and respond to many different extracellular signalling molecules, such as neurotransmitters, hormones and growth factors, will aid the identification of new therapeutic targets through which cardiovascular diseases can be combated.
Abstract: Understanding precisely how the heart can recognize and respond to many different extracellular signalling molecules, such as neurotransmitters, hormones and growth factors, will aid the identification of new therapeutic targets through which cardiovascular diseases can be combated. In recent years, we have learned more about the complex interactions that occur between the receptors and the signalling pathways of the heart and its environment. Most of these discoveries have focused on the most common type of cardiac receptor - the seven-transmembrane-spanning receptor or G-protein-coupled receptor.
943 citations
TL;DR: It is shown that T cell homeostasis requires T GFβ signaling in T cells, and a transgenic approach to abrogate the TGFβ response in key immune cells is developed.
943 citations
TL;DR: The evolving IL-17 family of ligands and receptors may play an important role in the homeostasis of tissues in health and disease beyond the immune system, as reviewed in this survey.
943 citations
TL;DR: It is concluded that diverse pathogens activate cells through TLR2 and proposed that this molecule is a central pattern recognition receptor in host immune responses to microbial invasion.
942 citations
TL;DR: BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival and is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAff-deficient mice.
Abstract: B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival
942 citations