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Regeneration (biology)

About: Regeneration (biology) is a(n) research topic. Over the lifetime, 22855 publication(s) have been published within this topic receiving 725856 citation(s). more


Journal ArticleDOI: 10.1126/SCIENCE.279.5356.1528
06 Mar 1998-Science
Abstract: Growth and repair of skeletal muscle are normally mediated by the satellite cells that surround muscle fibers. In regenerating muscle, however, the number of myogenic precursors exceeds that of resident satellite cells, implying migration or recruitment of undifferentiated progenitors from other sources. Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers. Genetically modified, marrow-derived myogenic progenitors could potentially be used to target therapeutic genes to muscle tissue, providing an alternative strategy for treatment of muscular dystrophies. more

Topics: Myogenesis (61%), Skeletal muscle (59%), Muscle tissue (53%) more

2,847 Citations

Journal ArticleDOI: 10.1002/JCB.20886
Arnold I. Caplan1, James E. Dennis1Institutions (1)
Abstract: Adult marrow-derived Mesenchymal Stem Cells (MSCs) are capable of dividing and their progeny are further capable of differentiating into one of several mesenchymal phenotypes such as osteoblasts, chondrocytes, myocytes, marrow stromal cells, tendon-ligament fibroblasts, and adipocytes. In addition, these MSCs secrete a variety of cytokines and growth factors that have both paracrine and autocrine activities. These secreted bioactive factors suppress the local immune system, inhibit fibrosis (scar formation) and apoptosis, enhance angiogenesis, and stimulate mitosis and differentiation of tissue-intrinsic reparative or stem cells. These effects, which are referred to as trophic effects, are distinct from the direct differentiation of MSCs into repair tissue. Several studies which tested the use of MSCs in models of infarct (injured heart), stroke (brain), or meniscus regeneration models are reviewed within the context of MSC-mediated trophic effects in tissue repair. more

2,559 Citations

Open accessJournal Article
01 Jan 1997-Science
Abstract: Liver regeneration after the loss of hepatic tissue is a fundamental parameter of liver response to injury. Recognized as a phenomenon from mythological times, it is now defined as an orchestrated response induced by specific external stimuli and involving sequential changes in gene expression, growth factor production, and morphologic structure. Many growth factors and cytokines, most notably hepatocyte growth factor, epidermal growth factor, transforming growth factor-α, interleukin-6, tumor necrosis factor-α insulin, and norepinephrine, appear to play important roles in this process. This review attempts to integrate the findings of the last three decades and looks toward clues as to the nature of the causes that trigger this fascinating organ and cellular response. more

Topics: Liver regeneration (58%), Regeneration (biology) (54%), Growth factor (54%) more

2,338 Citations

Journal ArticleDOI: 10.1126/SCIENCE.1067404
Larry L. Hench1, Julia M. Polak1Institutions (1)
08 Feb 2002-Science
Abstract: Whereas second-generation biomaterials were designed to be either resorbable or bioactive, the next generation of biomaterials is combining these two properties, with the aim of developing materials that, once implanted, will help the body heal itself. more

Topics: Bone regeneration (63%), Biomaterial (54%), Absorbable Implants (54%) more

2,295 Citations

Open accessJournal ArticleDOI: 10.1126/SCIENCE.1171643
26 Jun 2009-Science
Abstract: Stem cell fate is influenced by a number of factors and interactions that require robust control for safe and effective regeneration of functional tissue. Coordinated interactions with soluble factors, other cells, and extracellular matrices define a local biochemical and mechanical niche with complex and dynamic regulation that stem cells sense. Decellularized tissue matrices and synthetic polymer niches are being used in the clinic, and they are also beginning to clarify fundamental aspects of how stem cells contribute to homeostasis and repair, for example, at sites of fibrosis. Multifaceted technologies are increasingly required to produce and interrogate cells ex vivo, to build predictive models, and, ultimately, to enhance stem cell integration in vivo for therapeutic benefit. more

2,271 Citations

No. of papers in the topic in previous years

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Topic's top 5 most impactful authors

Kenneth D. Poss

55 papers, 6.9K citations

Michael T. Longaker

46 papers, 4.3K citations

Panagiotis A. Tsonis

41 papers, 2.2K citations

Elly M. Tanaka

39 papers, 2.3K citations

David L. Stocum

30 papers, 1.1K citations

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