Topic
Region of interest
About: Region of interest is a research topic. Over the lifetime, 7895 publications have been published within this topic receiving 104479 citations. The topic is also known as: ROI.
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TL;DR: Results from this study indicate that the FDG time-activity curve obtained from the LV ROI matched well with the arterial plasma curve, and the rMGU obtained by Patlak graphic analysis was in good agreement with direct curve fitting results.
Abstract: To estimate regional myocardial glucose utilization (rMGU) with positron emission tomography (PET) and 2-(/sup 18/F)fluoro-2-deoxy-D-glucose (FDG) in humans, we studied a method which simplifies the experimental procedure and is computationally efficient. This imaging approach uses a blood time-activity curve derived from a region of interest (ROI) drawn over dynamic PET images of the left ventricle (LV), and a Patlak graphic analysis. The spillover of radioactivity from the cardiac chambers to the myocardium is automatically removed by this analysis. Estimates of rMGU were obtained from FDG PET cardiac studies of six normal human subjects. Results from this study indicate that the FDG time-activity curve obtained from the LV ROI matched well with the arterial plasma curve. The rMGU obtained by Patlak graphic analysis was in good agreement with direct curve fitting results (r = 0.90). The average standard error of the estimate of the Patlak rMGU was low (3%). These results demonstrate the practical usefulness of a simplified method for the estimation of rMGU in humans by PET. This approach is noninvasive, computationally fast, and highly suited for developing parametric images of myocardial glucose utilization rate.
285 citations
TL;DR: It is suggested that 12 direction data are sufficient for reproducibly defining the core of large bundles but may be less sensitive to smaller pathways.
283 citations
TL;DR: An operational definition for identifying the problematic posterior border of the PT on magnetic resonance imaging (MRI) scans is proposed and an asymmetry in area and volume was introduced by using an alternative method - the 'knife-cut' method - for identifies the posterior border.
Abstract: The acquisition of definitive evidence for systematic hemispheric asymmetries in the size of the planum temporale (PT) has been restricted by difficulties in identifying, standardizing and measuring the region of interest. In this paper an operational definition for identifying the problematic posterior border of the PT on magnetic resonance imaging (MRI) scans is proposed. An interactive voxel-painting program was used to identify and label the PT simultaneously in horizontal, sagittal and coronal planes in MRI scans, transformed into the standardized Talairach-Tournoux stereo-taxic space, from 50 normal right-handed volunteers. Both grey matter volume and cortical surface area of the PT were measured, while controlling for individual variation in overall brain shape and volume. The labeled tissue was averaged together to produce a probability map in standardized space of the region of interest. The PT region is highly variable, with no single voxel being labeled with a probability of >65%. In this study there were no significant hemispheric differences in volume or area of the PT. An asymmetry in area and volume was introduced by using an alternative method - the 'knife-cut' method - for identifying the posterior border. Implications for functional neuroimaging of the PT are discussed.
268 citations
TL;DR: The results show that the evaluated DTI protocol is suitable for clinical application in pediatric population, and ADC showed significant negative correlation with age in 13 of 15 examined fiber tracts and FA increased significantly in three fiber tracts.
265 citations
TL;DR: VBM analyses replicated results of less left inferior and right superior frontal cortical GM in schizophrenia patients and uncovered a significantly lower concentration of GM in the middle and superior temporal gyri, sought but not detected using ROIs, but did not replicate the parietal changes.
264 citations