Showing papers on "Regulation of gene expression published in 1969"
TL;DR: Direct support for the idea that regulation of gene activity underlies cell differentiation comes from evidence that much of the genome in higher cell types is inactive and that different ribonucleic acids are synthesized in different cell types.
Abstract: Cell differentiation is based almost certainly on the regulation of gene activity, so that for each state of differentiation a certain set of genes is active in transcription and other genes are inactive. The establishment of this concept (1) has depended on evidence
indicating that the cells of an organism generally contain identical genomes (2). Direct support for the idea that regulation of gene activity underlies cell differentiation
comes from evidence that much of the genome in higher cell
types is inactive (3) and that different ribonucleic acids (RNA) are synthesized in different cell types (4).
1,898 citations
498 citations
TL;DR: The results indicate that hormonal stimulation of RNA synthesis is closely coupled to phosphorylation of nuclear proteins, and they suggest that nuclear phosphoproteins may be involved in the regulation of gene expression in mammary epithelial cells.
96 citations
67 citations
49 citations
12 citations