scispace - formally typeset
Search or ask a question
Topic

Renal medullary carcinoma

About: Renal medullary carcinoma is a research topic. Over the lifetime, 221 publications have been published within this topic receiving 6399 citations. The topic is also known as: renal medullary carcinoma & RMC.


Papers
More filters
Journal ArticleDOI
TL;DR: It is concluded that renal medullary carcinoma represents another example of renal disease associated with sickle cell disorders, and the other six are unilateral hematuria, papillary necrosis, nephrotic syndrome, renal infarction, inability to concentrate urine, and pyelonephritis.
Abstract: Over the last 22 years, we have encountered 34 examples of a highly aggressive neoplasm with a microscopic morphology that is highly predictive of finding sickled erythrocytes in the tissue. With the exception of one patient, all are believed to have had sickle cell trait or, in one case, hemoglobin

522 citations

Journal ArticleDOI
TL;DR: C cumulative evidence is convincing for associations with hematuria, renal papillary necrosis, hyposthenuria, splenic infarction, exertional rhabdomyolysis, and exercise-related sudden death.

311 citations

Journal ArticleDOI
TL;DR: Clear cell RCC is the most common subtype and has a less favorable prognosis than do papillary RCC and chromophobe RCC, but collecting duct carcinoma and renal medullary carcinoma are associated with aggressive clinical behavior and a poor prognosis.
Abstract: Renal cell carcinoma (RCC) is a cause of significant morbidity and mortality, with an estimated 35,000 new cases and 12,480 deaths in the United States in 2003. Recent advances in imaging technology, pathology, urology, and oncology permit early diagnosis of RCC and facilitate optimal management. The 2004 World Health Organization classification for renal neoplasms recognizes several distinct histologic subtypes of RCC. These subtypes include clear cell RCC, papillary RCC, chromophobe RCC, hereditary cancer syndromes, multilocular cystic RCC, collecting duct carcinoma, medullary carcinoma, mucinous tubular and spindle cell carcinoma, neuroblastoma-associated RCC, Xp11.2 translocation-TFE3 carcinoma, and unclassified lesions. Different histologic subtypes of RCC have characteristic histomorphologic and biologic profiles. Clear cell RCC is the most common subtype and has a less favorable prognosis (stage for stage) than do papillary RCC and chromophobe RCC. Collecting duct carcinoma and renal medullary carcinoma are associated with aggressive clinical behavior and a poor prognosis.

290 citations

Journal ArticleDOI
TL;DR: Sickle cell anemia and related hemoglobinopathies are associated with a large spectrum of renal abnormalities, such as impaired urinary concentrating ability, defects in urinary acidification and potassium excretion, and supranormal proximal tubular function as discussed by the authors.
Abstract: Sickle cell anemia and the related hemoglobinopathies are associated with a large spectrum of renal abnormalities. The patients have impaired urinary concentrating ability, defects in urinary acidification and potassium excretion, and supranormal proximal tubular function. The latter is manifest by increased secretion of creatinine and by reabsorption of phosphorus and beta(2)-microglobulin. Young patients with sickle cell disease (SCD) have supranormal renal hemodynamics with elevations in both effective renal plasma flow (ERPF) and glomerular filtration rate (GFR). These parameters decrease with age as well as following the administration of prostaglandin inhibitors. Proteinuria, a common finding in adults with sickle cell disease, may progress to the nephrotic syndrome. Proteinuria, hypertension, and increasing anemia predict end-stage renal disease (ESRD). While ESRD can be managed by dialysis and/or renal transplantation, there may be an increased rate of complications in renal transplant recipients with SCD. Hematuria is seen in individuals with all of the SCDs as well as with sickle cell trait. In most cases the etiology of the hematuria turns out to be benign. However, there does appear to be an increased association between SCD and renal medullary carcinoma. Therefore, those SCD patients who present with hematuria should initially undergo a thorough evaluation in order to exclude this aggressive neoplasm. Papillary necrosis may occur due to medullary ischemia and infarction. Erythropoietin levels are usually lower than expected for their degree of anemia and decrease further as renal function deteriorates. An abnormal balance of renal prostaglandins may be responsible for some of the changes in sickle cell nephropathy. Acute renal failure is a component of the acute multiorgan failure syndrome (MOFS). Finally, progression of sickle cell nephropathy to ESRD may be slowed by adequate control of hypertension and proteinuria. However, the prevention of the renal complications of SCD will require a cure for this genetic disorder.

288 citations

Journal Article
TL;DR: The concept of collecting duct carcinoma is expanding and should include the recently described renal medullary carcinoma that is associated with sickle cell trait.

276 citations

Network Information
Related Topics (5)
Metastasis
103.6K papers, 3.4M citations
74% related
Cancer
339.6K papers, 10.9M citations
73% related
Carcinogenesis
60.3K papers, 3.1M citations
73% related
Carcinoma
78.2K papers, 2.2M citations
72% related
Colorectal cancer
71.1K papers, 2.2M citations
72% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202114
202010
201916
201814
201721
201611