Topic
Resveratrol
About: Resveratrol is a research topic. Over the lifetime, 9348 publications have been published within this topic receiving 393838 citations. The topic is also known as: 3,4',5-stilbenetriol & 3,5,4'-trihydroxystilbene.
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TL;DR: Up to the present, conclusive evidence for its absorption by human subjectsin biologically significant amounts is lacking, and it is questionable that its powerful and beneficial in vitro activities are reproduced as a consequence of sustained moderate red wine consumption.
827 citations
TL;DR: It is found that resveratrol also directly inhibited the activity of COX-2, a phenolic antioxidant found in grapes and other food products, which is likely to be important for understanding the anti-cancer and anti-inflammatory properties of resver atrol.
773 citations
TL;DR: The results presented here intimate that consumption of high-dose resveratrol might be insufficient to elicit systemic levels commensurate with cancer chemopreventive efficacy, however, the high systemic levels of resver atrol conjugate metabolites suggest that their cancer chemosynthetic properties warrant investigation.
Abstract: The red grape constituent resveratrol possesses cancer chemopreventive properties in rodents. The hypothesis was tested that, in healthy humans, p.o. administration of resveratrol is safe and results in measurable plasma levels of resveratrol. A phase I study of oral resveratrol (single doses of 0.5, 1, 2.5, or 5 g) was conducted in 10 healthy volunteers per dose level. Resveratrol and its metabolites were identified in plasma and urine by high-performance liquid chromatography-tandem mass spectrometry and quantitated by high-performance liquid chromatography-UV. Consumption of resveratrol did not cause serious adverse events. Resveratrol and six metabolites were recovered from plasma and urine. Peak plasma levels of resveratrol at the highest dose were 539 +/- 384 ng/mL (2.4 micromol/L, mean +/- SD; n = 10), which occurred 1.5 h post-dose. Peak levels of two monoglucuronides and resveratrol-3-sulfate were 3- to 8-fold higher. The area under the plasma concentration curve (AUC) values for resveratrol-3-sulfate and resveratrol monoglucuronides were up to 23 times greater than those of resveratrol. Urinary excretion of resveratrol and its metabolites was rapid, with 77% of all urinary agent-derived species excreted within 4 h after the lowest dose. Cancer chemopreventive effects of resveratrol in cells in vitro require levels of at least 5 micromol/L. The results presented here intimate that consumption of high-dose resveratrol might be insufficient to elicit systemic levels commensurate with cancer chemopreventive efficacy. However, the high systemic levels of resveratrol conjugate metabolites suggest that their cancer chemopreventive properties warrant investigation.
755 citations
TL;DR: It is shown here that resveratrol is a substrate-specific activator of yeast Sir2 and human SirT1 and that in three different yeast strain backgrounds, resver atrol has no detectable effect on Sir2 activity in vivo, as measured by rDNA recombination, transcriptional silencing near telomeres, and life span.
747 citations
TL;DR: It is demonstrated that food supplementation with resveratrol prolongs lifespan and retards the expression of age-dependent traits in a short-lived vertebrate.
747 citations