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Retinal pigment epithelium

About: Retinal pigment epithelium is a research topic. Over the lifetime, 9261 publications have been published within this topic receiving 318170 citations. The topic is also known as: pigmented layer of optical retina.


Papers
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Journal ArticleDOI
TL;DR: The optical coherence tomograph is a new, noninvasive technical device that can obtain cross-sectional, high-resolution images-optical coherencetomographs (OCT)-of the retina that permits an accurate evaluation of various macular and chorioretinal pathologies and the early detection of glaucomatous damage.
Abstract: The evaluation of the optical coherence tomography (OCT) is based on the identification of differences in the relative reflectivity of different tissue layers and morphological changes in tissue structures. So the examination is able to localize and grossly demarcate inflammation in the vitreous cavity (by its dynamic analysis) or beneath retinal layers as well as detail retinal changes on the chronic phases of retinal disease like fibrosis, atrophy, or retinal edema.

4,458 citations

Journal ArticleDOI
TL;DR: This review summarizes the current knowledge of RPE functions and describes how failure of these functions causes loss of visual function.
Abstract: Located between vessels of the choriocapillaris and light-sensitive outer segments of the photoreceptors, the retinal pigment epithelium (RPE) closely interacts with photoreceptors in the maintenance of visual function. Increasing knowledge of the multiple functions performed by the RPE improved the understanding of many diseases leading to blindness. This review summarizes the current knowledge of RPE functions and describes how failure of these functions causes loss of visual function. Mutations in genes that are expressed in the RPE can lead to photoreceptor degeneration. On the other hand, mutations in genes expressed in photoreceptors can lead to degenerations of the RPE. Thus both tissues can be regarded as a functional unit where both interacting partners depend on each other.

2,387 citations

Journal ArticleDOI
TL;DR: A common detection and classification system is needed for epidemiologic studies of age-related maculopathy (ARM) and such a grading scheme for ARM is described in this paper.

1,871 citations

Journal ArticleDOI
TL;DR: The first description of hESC-derived cells transplanted into human patients with Stargardt's macular dystrophy and dry age-related macular degeneration is provided, with no signs of hyperproliferation, tumorigenicity, ectopic tissue formation, or apparent rejection after 4 months.

1,319 citations

Journal ArticleDOI
TL;DR: It was found that ARPE-19 cells exhibit morphological polarization when plated on laminin-coated Transwell-COL filters in medium with a low serum content and has structural and functional properties characteristic of RPE cells in vivo, suggesting that this cell line will be valuable for in vitro studies of retinal pigment epithelium physiology.

1,269 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023328
2022767
2021404
2020458
2019382
2018379