Rice bran oil

About: Rice bran oil is a research topic. Over the lifetime, 2102 publications have been published within this topic receiving 32504 citations.

Development and Characterization of a Self-Nanoemulsifying Drug Delivery System Comprised of Rice Bran Oil for Poorly Soluble Drugs

Abstract: Poor aqueous solubility and low bioavailability are limiting factors in the oral delivery of lipophilic drugs. In a formulation approach to overcome these limitations, rice bran (RB) oil was evaluated as drug carrier in the development of self-nanoemulsifying drug delivery systems (SNEDDS). The performance of RB in formulations incorporating Kolliphor RH40 or Kolliphor EL as surfactants and Transcutol HP as cosolvent was compared to a common oil vehicle, corn oil (CO). Serial dilutions of the preconcentrates were performed in various media [distilled water and simulated intestinal fluids mimicking fasted state (FaSSIF) and fed state (FeSSIF)] and at different dilution ratios to simulate the in vivo droplets' behavior. The developed SNEDDS were assessed by means of phase separation, droplet size, polydispersity index, and ζ-potential. Complex ternary diagrams were constructed to identify compositions exhibiting monophasic behavior, droplet size < 100 nm, and polydispersity index (PDI) < 0.25. Multifactor analysis and response surface areas intended to determine the factors significantly affecting droplet size. The oil capacity to accommodate lipophilic drugs was assessed via fluorescence spectroscopy based on the solvatochromic behavior of Nile Red. Solubility studies were performed to prepare fenofibrate- and itraconazole-loaded SNEDDS and assess their droplet size, whereas dissolution experiments were conducted in simulated intestinal fluids. Caco-2 cell viability studies confirmed the safety of the SNEDDS formulations at 1:100 and 1:1000 dilutions after cell exposure in culture for 4 h. The obtained results showed similar performance between RB and CO supporting the potential of RB as oil vehicle for the effective oral delivery of lipophilic compounds.

Factors affecting refining losses in rice (Oryza sativa L.) bran oil

Abstract: Components of rice bran oil have been assessed for their effect on refining losses. Rice bran oil used in the study had the following (percent) analysis: free fatty acids, 6.8; phosphatides, 1.25; wax, 2.85; monoglycerides, 1.67; diglycerides, 4.84, and oryzanol, 1.85; the rest (80.74) was mostly triglycerides. The phosphatides and mono- and diglycerides had no noticeable effect on refining losses at levels of up to 2% in the oil. Waxes and oryzanol increased the refining losses substantially. In model experiments where these were incorporated into peanut oil individually and in combination, the wax at as low a level as 1% increased the refining losses by about 80% more than control and the refining losses increased with concentration of wax. Oryzanol had a similar effect. When wax and oryzanol were present together in the oil, the effect was synergistic—the refining losses were higher than the sum of their individual effects. Phosphatides, mono- and diglycerides tended to reduce the adverse effect of wax and oryzanol. The main components responsible for higher than normal refining losses in rice bran oil have been identified as wax and oryzanol.

Effects of ultrasonication and thermal cooking pretreatments on the extractability and quality of cold press extracted rice bran oil.

Abstract: This research investigates the effects of different extraction processes on the extractability and quality of rice bran oil. The extraction processes included hexane extraction (HE) as Control 1, cold press extraction (CE) as Control 2, ultrasonic pre‐treatment combined with cold press extraction (UCE), and thermal cooking combined with cold press extraction (CCE). The results showed that oil extractability was positively correlated to ultrasonic power and duration; and to thermal cooking time. Meanwhile, the oil quality and ultrasonic intensity and thermal cooking period were inversely correlated. Specifically, the oxidative stability, and unsaturated fatty acids of short‐period CCE oil were significantly higher than those of long‐period CCE oil and higher‐power and longer‐duration UCE oil. Similar to HE and CE oils, oleic, linoleic, and palmitic acids were the dominant fatty acids in short‐period CCE oil. Essentially, short‐period CCE is optimal for rice bran oil extraction due to improved oil extractability and quality. PRACTICAL APPLICATIONS: Rice bran oil is an excellent source of unsaturated fatty acids and natural antioxidants. It also has many proven health benefits. There are two conventional production methods of rice bran oil: pressing and solvent extraction. While the pressing method achieves low oil extractability, solvent extraction could deteriorate the oil quality. This research, thus, proposes two chemical‐free extraction techniques for rice bran oil that improves the oil extractability and preserves the oil quality: ultrasonic pretreatment combined with cold press extraction (UCE) and thermal cooking pretreatment combined with cold press extraction (CCE). The findings are expected to offer a possible solution to the extractability‐quality challenges associated with the conventional extraction methods.

Palm oil and rice bran oil: Current status and future prospects

Abstract: The continued demand for edible oils by the ever increasing population makes it pertinent to explore new sources. In this direction, two new edible oils namely palm oil and rice bran oil have been subjected to nutritional and toxicological evaluations of their chemicals constituents. An attempt has been made in this article to assess the acceptability of the two oils based on the various investigations that have been carried out so far. Key words: Palm oil, rice bran oil, anti-oxidants, cholesterol fatty acids, phospholipids, tocopherols, oryzanol, cardiovascular diseases.

Cholesterol-lowering efficacy of unrefined bran oil from the pigmented black rice (Oryza sativa L cv. Suwon 415) in hypercholesterolemic rats

Abstract: The effects of dietary supplementation of the unrefined rice bran oil from ‘Suwon 415’ pigmented black rice (BRBO) on cholesterol metabolism and cellular antioxidant status were investigated in hypercholesterolemic rats. The significant reduction of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) concentrations was observed in the plasma of rats fed BRBO. BRBO also decreased plasma and hepatic oxidative stress as a result of increased levels of hepatic thiobarbituric acid reactive substances (TBARS) levels associated with the elevations of hepatic superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities together with increased plasma level of tocopherol. This study indicates that dietary BRBO supplement can leads to the improvement of overall cholesterol metabolism and antioxidant status even more effectively than ‘Chuchung’ white rice (WRBO). Consumption of BRBO may also protect the liver from oxidative damage caused by lipid peroxidation.