Showing papers on "Ring chromosome published in 1974"
TL;DR: It could be shown that the long arm was broken at region 3 band 4 and the short arm at region 1 band 1 and the manifold pattern of behavior of the ring chromosome and their results in mosaic karyotypes were analysed.
Abstract: A case of 13r was reported. By means of banding staining techniques it could be shown that the long arm was broken at region 3 band 4 and the short arm at region 1 band 1. The manifold pattern of behavior of the ring chromosome and their results in mosaic karyotypes were analysed.
50 citations
TL;DR: A 14-year-old child with a 13 ring chromosome presenting all the major malformative features which are characteristic for this syndrome is given, and on G-banding it was demonstrated that bands c and d of the long arm of No. 13 were preserved.
Abstract: Report is given of a 14-year-old child with a 13 ring chromosome presenting all the major malformative features which are characteristic for this syndrome. No retinoblastoma has sofar occurred, but on G-banding it was demonstrated that bands c and d of the long arm of No. 13 were preserved.
17 citations
Journal Article•
17 citations
TL;DR: The chromosome analysis of a 10-year-old boy with the clinical symptoms of cheilo-palato-gnatho-schisis and debility revealed an extra small chromosome fragment in most of his cells, which is supposed to be a minute ring chromosome.
Abstract: The chromosome analysis of a 10-year-old boy with the clinical symptoms of cheilo-palato-gnatho-schisis and debility revealed an extra small chromosome fragment in most of his cells. Mosaicism of karyotypes has led to the suggestion that the extra chromosome could be a minute ring chromosome. The occurrence of anaphase bridges and micronuclei gave the further evidence of the ring nature of this extra chromosome. Because of its minuteness, the origin of the extra chromosome was not determinable. A comparison of clinical symptoms with those of other known trisomy syndromes is not feasible. Due to the special behavior of the ring chromosome resulting in its gradual elimination, it is supposed that the percentage of euploid cells increases at the same rate.
12 citations
TL;DR: A 10-year-old mentally and physically retarded girl has a mosaic ring-4 chromosome that has increased from 9% to 72% in the past seven years.
Abstract: A 10-year-old mentally and physically retarded girl has a mosaic ring-4 chromosome. The number of ring chromosomes in her peripheral blood preparations has increased from 9% to 72% in the past seven years. The child had a low birth weight and has had several phenotypic changes.
11 citations
TL;DR: A mosaic 46, XY,–G,+ t(GqGq)/46,XY, rG was found in a boy with Down’s syndrome and the G- and Q-banding techniques allowed to identify the abnormal chromosomes.
Abstract: A mosaic 46, XY,–G,+ t(GqGq)/46, XY, rG was found in a boy with Down’s syndrome. The G- and Q-banding techniques allowed to identify the abnormal chromosomes: 46, XY,–21,+t(21q21q)/46, XY,–21,+r[t(21q
11 citations
Journal Article•
9 citations
TL;DR: In non‐permissive hybrid cells the development of monoclonal stem lines, associated with the persistence of the viral genome, has been demonstrated and the association of viral nucleic acid with host‐cell chromosomes has been confirmed by the in situ hybridization method.
Abstract: Chromosome re-arrangements have been found in human cells infected in vitro with adenovirus type 12. Dicentric and ring chromosomes and chromatid re-arrangements were induced in cells infected during transition from GI to S phase. In non-permissive hybrid cells the development of monoclonal stem lines, associated with the persistence of the viral genome, has been demonstrated. Persistence of the virus in these cells results in continued induction of the uncoiler region of human chromosome E17. The association of viral nucleic acid with host-cell chromosomes has been confirmed by the in situ hybridization method.
9 citations
TL;DR: In the lymphocytes of a girl with microcephalia, hypertelorism, antimongoloid palpebral slant, bilateral cataract, severe dental caries, systolic murmur, back-rotation of kidneys and severe psychomotoric retardation, a ring chromosome G was found in all cells scored.
Abstract: In the lymphocytes of a girl with microcephalia, hypertelorism, antimongoloid palpebral slant, bilateral cataract, severe dental caries, systolic murmur, back-rotation of kidneys and severe psychomotoric retardation, a ring chromosome G was found in all cells scored. Using the Giemsa banding technique it was possible to identify the ring chromosome as number 21. Similarity with previously published cases of partial G monosomy is discussed.
9 citations
TL;DR: It is suggested that during replication in normal meioses, sister ring-chromatids form mutually interlocked ring complexes that are resolved without genetic consequences at anaphase II, with the resolution owing at least in part to normal centromere function.
Abstract: It is shown that under the influence of an autosomal meiotic mutant that causes abnormalities in meiotic centromere function (mei-S332), ring-X chromosomes are frequently nonrecoverable. Evidence is presented that this nonrecoverability is caused by a failure of sister ring-chromatids to successfully effect an equational separation with resultant dominant lethality. Because mei-S332 results in meiotic abnormalities only after replication has been completed, and because ring chromosomes are normally transmitted with approximately the same efficiency as rod chromosomes, it is suggested that during replication in normal meioses, sister ring-chromatids form mutually interlocked ring complexes that are resolved without genetic consequences at anaphase II, with the resolution owing at least in part to normal centromere function.
7 citations