Topic
RNA
About: RNA is a research topic. Over the lifetime, 111695 publications have been published within this topic receiving 5475262 citations. The topic is also known as: ribonucleic acid.
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TL;DR: It is shown that loss of function of a putative RNA-directed RNA polymerase (RdRP) of C. elegans, RRF-3, results in a substantial enhancement of sensitivity to RNAi in diverse tissues.
609 citations
TL;DR: A technique is described for the isolation of tobacco mosaic virus (TMV) ribonucleic acid (RNA) of higher purity and, as will be shown in the subsequent paper, of increased stability.
608 citations
TL;DR: The recent advances in biological function of m6A modifications in human cancer are summarized, the potential therapeutic strategies are discussed and the molecular mechanisms underlyingm6A RNA methylation in various tumors are comprehensively clarified.
Abstract: N6-methyladenosine (m6A) is identified as the most common, abundant and conserved internal transcriptional modification, especially within eukaryotic messenger RNAs (mRNAs). M6A modification is installed by the m6A methyltransferases (METTL3/14, WTAP, RBM15/15B and KIAA1429, termed as “writers”), reverted by the demethylases (FTO and ALKBH5, termed as “erasers”) and recognized by m6A binding proteins (YTHDF1/2/3, IGF2BP1 and HNRNPA2B1, termed as “readers”). Acumulating evidence shows that, m6A RNA methylation has an outsize effect on RNA production/metabolism and participates in the pathogenesis of multiple diseases including cancers. Until now, the molecular mechanisms underlying m6A RNA methylation in various tumors have not been comprehensively clarified. In this review, we mainly summarize the recent advances in biological function of m6A modifications in human cancer and discuss the potential therapeutic strategies.
608 citations
TL;DR: Using X-ray crystallography, this work directly observed the path of mRNA in the 70S ribosome in Fourier difference maps at 7 A resolution, finding that at the interface, only about eight nucleotides are exposed, and bond almost exclusively to 16S rRNA.
608 citations
TL;DR: These findings raise several fundamental questions: How many ncRNAs are encoded by a genome?
Abstract: Noncoding RNAs (ncRNAs) have been found to have roles in a great variety of processes, including transcriptional regulation, chromosome replication, RNA processing and modification, messenger RNA stability and translation, and even protein degradation and translocation. Recent studies indicate that ncRNAs are far more abundant and important than initially imagined. These findings raise several fundamental questions: How many ncRNAs are encoded by a genome? Given the absence of a diagnostic open reading frame, how can these genes be identified? How can all the functions of ncRNAs be elucidated?
607 citations