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RNA

About: RNA is a research topic. Over the lifetime, 111695 publications have been published within this topic receiving 5475262 citations. The topic is also known as: ribonucleic acid.


Papers
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Journal ArticleDOI
18 Nov 2005-Cell
TL;DR: It is shown that both strands of siRNA get loaded onto Ago2 protein in Drosophila S2 cell extracts and this cleavage event is important for the removal of the anti-guide strand from Ago2protein and activation of RISC.

836 citations

Journal ArticleDOI
TL;DR: A novel class of small RNAs in the mouse male germline termed piwi-interacting RNAs (piRNAs) are identified, associated with MIWI, a spermatogenesis-specific PIWI subfamily member of the Argonaute protein family, suggesting their potential role in translational regulation.
Abstract: Small noncoding RNAs, including small interfering RNAs (siRNAs) and micro RNAs (miRNAs) of approximately 21 nucleotides (nt) in length, have emerged as potent regulators of gene expression at both transcriptional and post-transcriptional levels in diverse organisms. Here we report the identification of a novel class of small RNAs in the mouse male germline termed piwi-interacting RNAs (piRNAs). piRNAs are approximately 30 nt in length. They are expressed during spermatogenesis, mostly in spermatids. piRNAs are associated with MIWI, a spermatogenesis-specific PIWI subfamily member of the Argonaute protein family, and depend on MIWI for their biogenesis and/or stability. Furthermore, a subpopulation of piRNAs are associated with polysomes, suggesting their potential role in translational regulation.

833 citations

Journal ArticleDOI
M. Fleischhacker1, B. Schmidt
TL;DR: In the past few years many experiments showed that tumor-associated alterations can be detected at the DNA and RNA level, and laid the foundation for the development of assays for an early detection of cancer as well as for other clinical means.

832 citations

Journal ArticleDOI
15 Jan 2015-Cell
TL;DR: By extending guide RNAs to include effector protein recruitment sites, this work constructs modular scaffold RNAs that encode both target locus and regulatory action and applies this approach to flexibly redirect flux through a complex branched metabolic pathway in yeast.

831 citations

Journal ArticleDOI
TL;DR: Long intergenic non-coding RNA genes have diverse features that distinguish them from mRNA-encoding genes and exercise functions such as remodelling chromatin and genome architecture, RNA stabilization and transcription regulation, including enhancer-associated activity.
Abstract: Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish them from mRNA-encoding genes and exercise functions such as remodelling chromatin and genome architecture, RNA stabilization and transcription regulation, including enhancer-associated activity. Some genes currently annotated as encoding lincRNAs include small open reading frames (smORFs) and encode functional peptides and thus may be more properly classified as coding RNAs. lincRNAs may broadly serve to fine-tune the expression of neighbouring genes with remarkable tissue specificity through a diversity of mechanisms, highlighting our rapidly evolving understanding of the non-coding genome.

829 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20241
20233,706
20227,117
20214,436
20204,465
20193,923