Topic
Root canal
About: Root canal is a research topic. Over the lifetime, 13227 publications have been published within this topic receiving 292034 citations. The topic is also known as: tooth root.
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TL;DR: Forty-five root canals were cleaned, shaped, and then obturated with gutta-percha and root canal sealer, using a lateral condensation technique, to determine the number of days required for Staphylococcus epidermidis and Proteus vulgaris to penetrate the entireRoot canals.
597 citations
TL;DR: This study provides the first evidence showing that pulp- like tissue can be regenerated de novo in emptied root canal space by stem cells from apical papilla and dental pulp stem cells that give rise to odontoblast-like cells producing dentin-like tissue on existing dentinal walls.
Abstract: The ultimate goal of this study is to regenerate lost dental pulp and dentin via stem/progenitor cell–based approaches and tissue engineering technologies. In this study, we tested the possibility of regenerating vascularized human dental pulp in emptied root canal space and producing new dentin on existing dentinal walls using a stem/progenitor cell–mediated approach with a human root fragment and an immunocompromised mouse model. Stem/progenitor cells from apical papilla and dental pulp stem cells were isolated, characterized, seeded onto synthetic scaffolds consisting of poly-D,L-lactide/glycolide, inserted into the tooth fragments, and transplanted into mice. Our results showed that the root canal space was filled entirely by a pulp-like tissue with well-established vascularity. In addition, a continuous layer of dentin-like tissue was deposited onto the canal dentinal wall. This dentin-like structure appeared to be produced by a layer of newly formed odontoblast-like cells expressing dentin sialophos...
587 citations
TL;DR: In this paper, the authors investigated the effect of a mixture of a tetracycline isomer, an acid, and a detergent (MTAD) as a final rinse on the surface of instrumented root canals.
547 citations
01 Jan 2003
TL;DR: Results show that MTAD is an effective solution for the removal of the smear layer and does not significantly change the structure of the dentinal tubules when canals are irrigated with sodium hypochlorite and followed with a final rinse of MTAD.
Abstract: Various organic acids, ultrasonic instruments, and lasers have been used to remove the smear layer from the surface of instrumented root canals. The purpose of this study was to investigate the effect of a mixture of a tetracycline isomer, an acid, and a detergent (MTAD) as a final rinse on the surface of instrumented root canals. Forty-eight extracted maxillary and mandibular single-rooted human teeth were prepared by using a combination of passive step-back and rotary 0.04 taper nickel-titanium files. Sterile distilled water or 5.25% sodium hypochlorite was used as intracanal irrigant. The canals were then treated with 5 ml of one of the following solutions as a final rinse: sterile distilled water, 5.25% sodium hypochlorite, 17% EDTA, or a new solution, MTAD. The presence or absence of smear layer and the amount of erosion on the surface of the root canal walls at the coronal, middle, and apical portion of each canal were examined under a scanning electron microscope. The results show that MTAD is an effective solution for the removal of the smear layer and does not significantly change the structure of the dentinal tubules when canals are irrigated with sodium hypochlorite and followed with a final rinse of MTAD. Microscopic examinations of root canals show that they are irregular and complex systems, with many cul-de-sacs, fins, and lateral canals. Additionally, numerous dentinal tubules open onto the root canal surface. When the dental pulp undergoes pathologic changes caused by trauma or carious invasion, the root canal system becomes susceptible to infection by several species of bacteria, with their toxins and their by-products. The microorganisms present in the root canal not only invade the anatomic irregularities of the root
540 citations
TL;DR: The combination of NaOCl and EDTA used alternately completely removed the smear layer from the instrumented root canal surfaces as well as the pulpal remnants and predentin from the uninstrumented surfaces and caused the exposed calcospherites on the unin instrumented surfaces to have an eroded appearance.
539 citations