Showing papers on "SAIDS Vaccines published in 2008"
TL;DR: Questions regarding what constitutes an effective T cell response and how such responses could be elicited by vaccination remain open.
39 citations
TL;DR: The standard model of viral dynamics is used to derive the reproductive ratio from the peak viral load and nadir of target cell numbers in acute infection and it is demonstrated that vaccination can reduce the reproductive Ratio 2.3- and 2-fold, respectively.
Abstract: The dynamics of HIV infection have been studied in humans and in a variety of animal models. The standard model of infection has been used to estimate the basic reproductive ratio of the virus, calculated from the growth rate of virus in acute infection. This method has not been useful in studying the effects of vaccination, since, for the vaccines developed so far, early growth rates of virus do not differ between control and vaccinated animals. Here, we use the standard model of viral dynamics to derive the reproductive ratio from the peak viral load and nadir of target cell numbers in acute infection. We apply this method to data from studies of vaccination in SHIV and SIV infection and demonstrate that vaccination can reduce the reproductive ratio by 2.3- and 2-fold, respectively. This method allows the comparison of vaccination efficacies among different viral strains and animal models in vivo.
16 citations