Topic
Seborrheic keratosis
About: Seborrheic keratosis is a research topic. Over the lifetime, 1127 publications have been published within this topic receiving 15353 citations. The topic is also known as: Keratosis Seborrheica & Basal Cell Papilloma.
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TL;DR: The tested algorithm performance was comparable to that of 16 dermatologists, and additional images with a broader range of ages and ethnicities should be collected to improve the performance of convolutional neural network.
435 citations
TL;DR: Different morphologic types of vessels are associated with different melanocytic or nonmelanocytic skin tumors, and the recognition of distinctive vascular structures may be helpful for diagnostic purposes, especially when the classic pigmented dermoscopic structures are lacking.
Abstract: Objectives To describe the different vascular structures seen by dermoscopy and to evaluate their association with various melanocytic and nonmelanocytic skin tumors in a large series of cases. Design Digital dermoscopic images of the lesions were evaluated for the presence of various morphologic types of vessels. Setting Specialized university clinic. Patients From a larger database, 531 excised lesions (from 517 patients) dermoscopically showing any type of vascular structures were included. Main Outcome Measures The frequency and positive predictive value of the different vascular structures seen in various tumors were calculated, and the differences were evaluated by the {chi}2 or Fisher exact test. Results Arborizing vessels were seen in 82.1% of basal cell carcinomas, with a 94.1% positive predictive value (P<.001). Dotted vessels were generally predictive for a melanocytic lesion (90.0%, P<.001), and were especially seen in Spitz nevi (77.8% of lesions). In melanoma, linear-irregular, dotted, and polymorphous/atypical vessels were the most frequent vascular structures, whereas milky-red globules/areas were the most predictive ones (77.8%, P = .003). The presence of erythema was most predictive for Clark nevus, whereas comma, glomerular, crown, and hairpin vessels were significantly associated with dermal/congenital nevi, Bowen disease, sebaceous hyperplasia, and seborrheic keratosis, respectively (P<.001 for all). Conclusions Different morphologic types of vessels are associated with different melanocytic or nonmelanocytic skin tumors. Therefore, the recognition of distinctive vascular structures may be helpful for diagnostic purposes, especially when the classic pigmented dermoscopic structures are lacking.
335 citations
TL;DR: It is proposed that neural network analysis of near-infrared Fourier transform Raman spectra could provide a novel method for rapid, automated skin cancer diagnosis on unstained skin samples.
333 citations
TL;DR: Lifetime sun exposure appeared to be associated with a lower risk of malignant melanoma, despite the fact that lifetime sun exposure did not diminish the number of melanocytic nevi or atypical nevi, and painful sunburns nor lifetimeSun exposure were associated with an increased risk of seborrheic warts.
314 citations
TL;DR: Its association with malignant acanthosis nigricans is one of several of its features that support its legitimacy as a true paraneoplastic disorder.
Abstract: The sign of Leser-Trelat is rare. It is defined as the sudden eruption of multiple seborrheic keratoses caused by a malignancy. Because both seborrheic keratoses and cancer are common in the elderly, it is not always easy to tell from the literature or in any given patient if this sign is present. In fact, its validity has been questioned. Its association with malignant acanthosis nigricans is one of several of its features that support its legitimacy as a true paraneoplastic disorder.
293 citations