Topic
Selenium
About: Selenium is a research topic. Over the lifetime, 21192 publications have been published within this topic receiving 429715 citations. The topic is also known as: Se & selen.
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TL;DR: Selenium is needed for the proper functioning of the immune system, and appears to be a key nutrient in counteracting the development of virulence and inhibiting HIV progression to AIDS.
3,359 citations
01 Jan 1980
TL;DR: In this paper, the essential roles of arsenic, fluorine, nickel, silicon, tin and vanadium have in recent years been established in animal nutrition, and they are known as trace elements, minor elements or micro-nutrients.
Abstract: Fifteen or more elements present in rocks and soils normally in very small amounts are essential for plant and/or animal nutrition. By the nature of their low abundance in natural uncontaminated earth materials or plants, they are known as trace elements, minor elements or micro-nutrients. Boron, copper, iron, manganese, molybdenum, silicon, vanadium and zinc are required by plants; copper, cobalt, iodine, iron, manganese, molybdenum, selenium and zinc by animals. In addition essential roles of arsenic, fluorine, nickel, silicon, tin and vanadium have in recent years been established in animal nutrition.
3,339 citations
TL;DR: Two peaks of glutathione peroxidase activity were present in the Sephadex G-150 gel filtration chromatogram of rat liver supernatant when 1.5 mM cumene hydroperoxide was used as substrate, and the second peak represents a second glutathienase activity which catalyzes the destruction of organic hydroperoxides but has little activity toward H 2 O 2 and which persists in severe selenium deficiency.
3,181 citations
01 Jan 2001
TL;DR: The essential trace mineral, selenium, is of fundamental importance to human health as mentioned in this paper, and it is needed for the proper functioning of the immune system, and appears to be a key nutrient in counteracting the development of virulence and inhibiting HIV progression to AIDS.
Abstract: The essential trace mineral, selenium, is of fundamental importance to human health. As a constituent of selenoproteins, selenium has structural and enzymic roles, in the latter context being best-known as an antioxidant and catalyst for the production of active thyroid hormone. Selenium is needed for the proper functioning of the immune system, and appears to be a key nutrient in counteracting the development of virulence and inhibiting HIV progression to AIDS. It is required for sperm motility and may reduce the risk of miscarriage. Deficiency has been linked to adverse mood states. Findings have been equivocal in linking selenium to cardiovascular disease risk although other conditions involving oxidative stress and inflammation have shown benefits of a higher selenium status. An elevated selenium intake may be associated with reduced cancer risk. Large clinical trials are now planned to confirm or refute this hypothesis. In the context of these health effects, low or diminishing selenium status in some parts of the world, notably in some European countries, is giving cause for concern.
3,068 citations
TL;DR: The crucial factor that needs to be emphasised with regard to the health effects of selenium is the inextricable U-shaped link with status; whereas additional seenium intake may benefit people with low status, those with adequate-to-high status might be affected adversely and should not take selenum supplements.
2,297 citations