Topic
Selenium
About: Selenium is a research topic. Over the lifetime, 21192 publications have been published within this topic receiving 429715 citations. The topic is also known as: Se & selen.
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TL;DR: Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one 1, a non-toxic selenium containing heterocyclic compound has been shown to display both anti- inflammatory activity in vivo and GSH-Px-like activity in vitro as mentioned in this paper.
Abstract: Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one 1, a non-toxic selenium containing heterocyclic compound has been shown to display both anti- inflammatory activity in vivo and GSH-Px-like activity in vitro. Using 1H and 77Se NMR we investigated the mechanism of reduction of hydroperoxides by thiols in the presence of 1. A catalytic cycle depending on the formation of diselenides and selenenylsulfides was found. The selenenic acid oxidation level present in compound 1 is particularly stable because of the intramolecular cyclisation. This contrasts with previously reported results concerning the oxidation of organoselenium compounds.
119 citations
TL;DR: The results indicate that, in order to maintain consistent removal in more realistic systems, a pre-treatment process to manage sulfate will be necessary as indicated for other adsorbents implemented for selenium adsorption in aqueous systems.
119 citations
TL;DR: The results of these studies show that the selenium level in the male gonads is maintained by regulation mechanisms and that the supply of sufficient amounts of Selenium to the testes has priority over the supply to other tissues.
Abstract: In male rats, fed for 10 weeks on a Torula yeast-based, low selenium and low vitamin E diet, the selenium level and the glutathione peroxidase activity in the blood and in several tissues decreased by 50 to 98% compared with animals that received the same basal diet supplemented with 0.25 mg Se/kg sodium selenite. In the testes, however, the selenium content did not differ from that of the control animals. Despite the low selenium levels in the extragonadal tissues and their increased requirement of this element due to the low vitamin E status, the selenium from an intravenously injected dose of sodium selenite was retained above all in the testes. After the removal of the pituitary gland, because of the decrease in the testicular mass and in the selenium content in the remaining testicular tissue, the amount of selenium in the testes was greatly reduced. After administration of pregnant mare's serum gonadotropin (PMS), due to the regeneration of the tissue and the simultaneous restoration of the selenium content, a relatively large amount of this element was shifted to the testes even though the selenium status in the other tissues was low. The results of these studies show that the selenium level in the male gonads is maintained by regulation mechanisms and that the supply of sufficient amounts of selenium to the testes has priority over the supply to other tissues.
119 citations
119 citations
TL;DR: It was found that mercury and selenium exist in the form of HgSe in the liver of northern fur seal and the existence of a solid solution Hg(Se, S) as granules in black-footed albatross was disclosed.
Abstract: Marine mammals and seabirds tend to exhibit high accumulations of mercury, cadmium, and selenium in their livers and kidneys. In this study, chemical forms of mercury, cadmium, and selenium accumul...
119 citations