Topic
Selenium
About: Selenium is a research topic. Over the lifetime, 21192 publications have been published within this topic receiving 429715 citations. The topic is also known as: Se & selen.
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TL;DR: The bioanalytical characterization of different parameters such as cell proliferation, apoptosis and cell cycle pattern on HepG2 cells has shown the unique properties of this relatively novel compound that support and complete prior evidences for future applications as chemotherapeutic agent.
110 citations
Book•
01 May 1993
TL;DR: In this article, the status of cadmium, lead, cobalt, and selenium in soils and plants of thirty countries was investigated and the results showed that lead, lead and cobalt were the most abundant elements.
Abstract: Status of cadmium, lead, cobalt, and selenium in soils and plants of thirty countries , Status of cadmium, lead, cobalt, and selenium in soils and plants of thirty countries , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
110 citations
TL;DR: The present study suggests that toxicity of nanoparticles can largely vary between different species and concludes that the evaluation of nanotoxicology should be carried out on a case-by-case basis.
110 citations
TL;DR: Findings indicate that tandem Sepp1‐apoER2 interactions supply selenium for maintenance of brain neurons, and one interaction is at the blood‐brain barrier, and the other is within the brain to maintain an essential seenium pool that protects against neurodegeneration.
Abstract: Selenoprotein P (Sepp1) and its receptor, apolipoprotein E receptor 2 (apoER2), account for brain retaining selenium better than other tissues. The primary sources of Sepp1 in plasma and brain are hepatocytes and astrocytes, respectively. ApoER2 is expressed in varying amounts by tissues; within the brain it is expressed primarily by neurons. Knockout of Sepp1 or apoER2 lowers brain selenium from ∼120 to ∼50 ng/g and leads to severe neurodegeneration and death in mild selenium deficiency. Interactions of Sepp1 and apoER2 that protect against this injury have not been characterized. We studied Sepp1, apoER2, and brain selenium in knockout mice. Immunocytochemistry showed that apoER2 mediates Sepp1 uptake at the blood-brain barrier. When Sepp1(-/-) or apoER2(-/-) mice developed severe neurodegeneration caused by mild selenium deficiency, brain selenium was ∼35 ng/g. In extreme selenium deficiency, however, brain selenium of ∼12 ng/g was tolerated when both Sepp1 and apoER2 were intact in the brain. These findings indicate that tandem Sepp1-apoER2 interactions supply selenium for maintenance of brain neurons. One interaction is at the blood-brain barrier, and the other is within the brain. We postulate that Sepp1 inside the blood-brain barrier is taken up by neurons via apoER2, concentrating brain selenium in them.
110 citations
TL;DR: In this paper, the available phase-diagram data for the Cu-Se system are critically evaluated, and the T-x and p-T phase diagrams are optimized, and thermodynamic properties and polymorphism of copper selenides are analyzed.
Abstract: The available phase-diagram data for the Cu-Se system are critically evaluated, and theT-x andp-T phase diagrams are optimized. The thermodynamic properties and polymorphism of copper selenides are analyzed.
110 citations