Topic
Selenium
About: Selenium is a research topic. Over the lifetime, 21192 publications have been published within this topic receiving 429715 citations. The topic is also known as: Se & selen.
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TL;DR: The question of whether a small increase in selenium intake might help prevent preeclampsia in susceptible women is raised, in the light of the reduction inSelenium status in a number of European countries in recent years.
146 citations
TL;DR: The reduction of Se in the liver and plasma during APR may be associated with the increased CRP synthesis in the Liver by inducing acute phase response (APR) in rats by injection of lipopolysaccharide.
146 citations
TL;DR: Using X-ray absorption spectroscopy, a new arsenic−selenium compound is identified in the bile of rabbits injected with aqueous selenite and arsenite solutions, which provides a molecular basis for the antagonistic interaction between these metalloid compounds and a potential explanation of the association of cancer with prolonged intake of inorganic arsenic in humans.
Abstract: Among the most startling observations in mammalian toxicology is that a lethal dose of selenium can be overcome by an otherwise lethal dose of arsenic. We report the molecular basis of this antagonism. Using X-ray absorption spectroscopy we have identified a new arsenic−selenium compound in the bile of rabbits injected with aqueous selenite and arsenite solutions. This compound contains equimolar arsenic and selenium and exhibits X-ray absorption spectra which are essentially identical with those of a synthetic species in solution which we have identified spectroscopically as the seleno-bis(S-glutathionyl) arsinium ion. The in vivo detection of this compound links the mammalian metabolism of arsenite, selenite, and sulfur. It provides a molecular basis for the antagonistic interaction between these metalloid compounds, and a potential explanation of the association of cancer with prolonged intake of inorganic arsenic in humans.
146 citations
TL;DR: Biogenic selenium (Se) NPs extracted from the Caspian Sea showed a moderately inhibitory effect on MMP‐2 expression and the cytotoxicity effect of these extracted biogenic Se NPs on the fibrosarcoma cell line (HT‐1080) proliferation was studied.
Abstract: Today, green synthesis of nanoparticles is attracting increasing attention. In the present study, the Bacillus sp. MSh-1 was isolated from the Caspian Sea (located in the northern part of Iran) and identified by various identification tests and 16S ribosomal DNA analysis. The reduction time course study of selenium ion (Se(4+)) reduction by using this test strain was performed in a liquid culture broth. Then, the intracellular NPs (nanoparticles) were released by the liquid nitrogen disruption method and thoroughly purified using an n-octyl alcohol water extraction system. Characterization of the separated NPs on features such as particle shape, size and purity was carried out with different devices. The energy dispersive X-ray and X-ray diffraction patterns showed that the purified NPs consisted of only selenium and are amorphous respectively. In addition, the transmission electron micrograph showed that the separated NPs were spherical and 80-220 nm in size. Furthermore, the cytotoxicity effect of these extracted biogenic selenium (Se) NPs on the fibrosarcoma cell line (HT-1080) proliferation and the inhibitory effect of the Se NPs on MMP-2 (matrix metalloproteinase-2) expression were studied using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide] assay and gelatin zymography. Biogenic Se NPs showed a moderately inhibitory effect on MMP-2 expression.
146 citations
TL;DR: X-ray absorption fine structure spectroscopy has been used to determine directly the oxidation states and speciation of selenium and arsenic in fly ash samples collected from full-scale utility plants, suggesting that the postcombustion behavior and capture of both of these elements are likely controlled by the same dominant element or phase in each type of fly ash.
Abstract: X-ray absorption fine structure spectroscopy has been used to determine directly the oxidation states and speciation of selenium and arsenic in 10 fly ash samples collected from full-scale utility plants. Such information is needed to assess the health risk posed by these elements in fly ash and to understand their behavior during combustion and in fly ash disposal options, such as sequestration in tailings ponds. Selenium is found predominantly as Se(IV) in selenite (SeO32-) species, whereas arsenic is found predominantly as As(V) in arsenate (AsO43-) species. Two distinct types of selenite and arsenate spectra were observed depending upon whether the fly ash was derived from eastern U.S. bituminous (Fe-rich) coals or from western subbituminous or lignite (Ca-rich) coals. Similar spectral details were observed for both arsenic and selenium in the two different types of fly ash, suggesting that the post-combustion behavior and capture of both of these elements are likely controlled by the same dominant el...
145 citations