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Self-healing hydrogels

About: Self-healing hydrogels is a(n) research topic. Over the lifetime, 34980 publication(s) have been published within this topic receiving 1259816 citation(s). more


Journal ArticleDOI: 10.1016/S0169-409X(01)00239-3
Allan S. Hoffman1Institutions (1)
Abstract: This article reviews the composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices. The most important properties of hydrogels relevant to their biomedical applications are also identified, especially for use of hydrogels as drug and cell carriers, and as tissue engineering matrices. more

Topics: Self-healing hydrogels (64%)

4,906 Citations

Journal ArticleDOI: 10.1016/S0142-9612(03)00340-5
Jeanie L. Drury1, David J. Mooney1Institutions (1)
01 Nov 2003-Biomaterials
Abstract: Polymer scaffolds have many different functions in the field of tissue engineering. They are applied as space filling agents, as delivery vehicles for bioactive molecules, and as three-dimensional structures that organize cells and present stimuli to direct the formation of a desired tissue. Much of the success of scaffolds in these roles hinges on finding an appropriate material to address the critical physical, mass transport, and biological design variables inherent to each application. Hydrogels are an appealing scaffold material because they are structurally similar to the extracellular matrix of many tissues, can often be processed under relatively mild conditions, and may be delivered in a minimally invasive manner. Consequently, hydrogels have been utilized as scaffold materials for drug and growth factor delivery, engineering tissue replacements, and a variety of other applications. more

Topics: Self-healing hydrogels (57%), Scaffold (53%), Tissue engineering (53%)

4,191 Citations

Journal ArticleDOI: 10.1021/CR000108X
Kuen Yong Lee1, David J. Mooney1Institutions (1)
31 May 2001-Chemical Reviews
Topics: Self-healing hydrogels (56%)

4,117 Citations

Open accessJournal ArticleDOI: 10.1016/J.PROGPOLYMSCI.2011.06.003
Kuen Yong Lee1, David J. Mooney1Institutions (1)
Abstract: Alginate is a biomaterial that has found numerous applications in biomedical science and engineering due to its favorable properties, including biocompatibility and ease of gelation. Alginate hydrogels have been particularly attractive in wound healing, drug delivery, and tissue engineering applications to date, as these gels retain structural similarity to the extracellular matrices in tissues and can be manipulated to play several critical roles. This review will provide a comprehensive overview of general properties of alginate and its hydrogels, their biomedical applications, and suggest new perspectives for future studies with these polymers. more

Topics: Self-healing hydrogels (51%)

4,097 Citations

Journal ArticleDOI: 10.1016/S0169-409X(01)00203-4
Yong Qiu1, Kinam Park1Institutions (1)
Abstract: Environmentally sensitive hydrogels have enormous potential in various applications. Some environmental variables, such as low pH and elevated temperatures, are found in the body. For this reason, either pH-sensitive and/or temperature-sensitive hydrogels can be used for site-specific controlled drug delivery. Hydrogels that are responsive to specific molecules, such as glucose or antigens, can be used as biosensors as well as drug delivery systems. Light-sensitive, pressure-responsive and electro-sensitive hydrogels also have the potential to be used in drug delivery and bioseparation. While the concepts of these environment-sensitive hydrogels are sound, the practical applications require significant improvements in the hydrogel properties. The most significant weakness of all these external stimuli-sensitive hydrogels is that their response time is too slow. Thus, fast-acting hydrogels are necessary, and the easiest way of achieving that goal is to make thinner and smaller hydrogels. This usually makes the hydrogel systems too fragile and they do not have mechanical strength necessary in many applications. Environmentally sensitive hydrogels for drug delivery applications also require biocompatibility. Synthesis of new polymers and crosslinkers with more biocompatibility and better biodegradability would be essential for successful applications. Development of environmentally sensitive hydrogels with such properties is a formidable challenge. If the achievements of the past can be extrapolated into the future, however, it is highly likely that responsive hydrogels with a wide array of desirable properties can be made. more

Topics: Self-healing hydrogels (65%), Drug delivery (51%)

3,991 Citations

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Topic's top 5 most impactful authors

Ali Khademhosseini

157 papers, 27.7K citations

Jian Ping Gong

153 papers, 11.9K citations

Kristi S. Anseth

134 papers, 21.9K citations

Nicholas A. Peppas

132 papers, 23.5K citations

Jason A. Burdick

119 papers, 17K citations

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