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Semen analysis

About: Semen analysis is a research topic. Over the lifetime, 4909 publications have been published within this topic receiving 143225 citations.


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TL;DR: Surgery-induced massive weight loss does not interfere with sperm quality, while it increased the quality of sexual function, TT, FT and FSH and reduced PRL.
Abstract: Purpose:Positive impact of weight loss on sexual function and hormones has been demonstrated, and male fertility in this scenario is to be better defined. We evaluated the impact of lifestyle modifications and gastric bypass on sperm quality.Methods:We prospectively studied 20 morbidly obese men during 24 months, randomized for intervention: lifestyle modifications (exercise and diet) for 4 months and subsequently gastric bypass (n = 10); and control: follow-up (n = 10). All patients underwent International Index of Erectile Function (IIEF-5) questionnaire, serum estradiol, prolactin (PRL), luteinizing and follicle-stimulating hormones (LH and FSH), free and total testosterones (FT and TT) and semen analysis at baseline (time 0), surgery 4 months later baseline (time 1) and final evaluation 24 months (time 2).Results:Intervention group presented significant reduction in body mass index (BMI) at times 1 and 2, compared to control. There were no significant differences among sperm parameters between groups ...

76 citations

Journal ArticleDOI
TL;DR: It could be concluded that the neutrophil polymorphonuclear leukocytes were the only 'round cells' showing a positive reaction in the semen samples, and the potential influence of inflammatory cells in the sperm samples on infertility/subfertility is discussed.
Abstract: The aims of this review are to evaluate the morphological differences between 'round cells' of spermatogenic and non-spermatogenic origin in semen. The latter group includes inflammatory cells like neutrophils, lymphocytes, and macrophages, and epithelial cells. A comparison was made between non-spermatogenic cells in semen samples and inflammatory cells in blood smears, using various staining procedures commonly used in routine andrology laboratories. The result presented in this review confirmed previously published data. In blood smears as well as in semen samples, only neutrophil leukocytes (both eosinophilic and basophilic) showed a positive reaction when exposed to the peroxidase stain. Lymphocytes, macrophages and other 'round cells' such as epithelial cells and spermatogenesis cells remained negative. It could be concluded that the neutrophil polymorphonuclear leukocytes were the only 'round cells' showing a positive reaction in the semen samples. The presence of specifically stained neutrophils in semen was considered to be compatible with an infection and/or a subsequent inflammatory reaction in the male genital tract. The potential influence of inflammatory cells in the sperm samples on infertility/subfertility is discussed. However, the question of determining if morphologically abnormal, degenerated spermatids are still capable of fertilizing an oocyte in vitro is not addressed in this review.

76 citations

Journal ArticleDOI
TL;DR: Reduced parameters in human semen quality are positively associated with As exposure in a reproductive-age Chinese cohort after adjusting for age, body mass index, abstinence, smoking and drinking habits.
Abstract: Background: Recent observations in in vitro and in vivo models suggest that arsenic (As) is an endocrine disruptor at environmentally-relevant levels. When exposed to As, male rats and mice show steroidogenic dysfunction that can lead to infertility. However, the possible effects of As on human male semen quality remain obscure.

76 citations

Journal ArticleDOI
TL;DR: The genomic damage evident in spermatozoa of type 1 diabetics may have important implications for their fertility and the outcome of pregnancies fathered by these individuals.
Abstract: The effects of diabetes mellitus on male reproductive health have not been clearly defined. A previous publication from this group reported significantly higher levels of nuclear DNA fragmentation and mitochondrial DNA deletions in spermatozoa from men with type 1 diabetes. This study compared semen profiles, sperm DNA fragmentation and levels of oxidative DNA modification in spermatozoa of diabetic and non-diabetic men. Semen samples from 12 non-diabetic, fertile men and 11 type 1 diabetics were obtained and subjected to conventional light microscopic semen analysis. Nuclear DNA fragmentation was assessed using an alkaline Comet assay and concentrations of 7,8-dihydro-8-oxo-2-deoxyguanosine (8-OHdG), an oxidative adduct of the purine guanosine, were assessed by high-performance liquid chromatography. Conventional semen profiles were similar in both groups, whilst spermatozoa from type 1 diabetics showed significantly higher levels of DNA fragmentation (44% versus 27%; P < 0.05) and concentrations of 8-OHdG (3.6 versus 2.0 molecules of 8-OHdG per 10(5) molecules of deoxyguanosine; P < 0.05). Furthermore, a positive correlation was observed between DNA fragmentation and concentrations of 8-OHdG per 10(5) molecules of deoxyguanosine (rs = 0.7, P < 0.05). The genomic damage evident in spermatozoa of type 1 diabetics may have important implications for their fertility and the outcome of pregnancies fathered by these individuals.

76 citations

Journal ArticleDOI
TL;DR: Curcumin nanomicelle supplementation resulted in a statistically significant improvement in plasma levels of total antioxidant capacity, malondialdehyde, C‐reactive protein, and tumor necrosis factor a in comparison to the placebo.
Abstract: At least 50% of infertile couple's problems are related to male factor infertility. This Randomized, Double-Blind, Placebo-Controlled Clinical Trial conducted in Urology unit of Infertility Clinic on 60 infertile men. Patients were randomly assigned to one of intervention and placebo (n = 30) groups. Finally, 28 subjects in each group completed the study. Participants in the intervention group took daily 80 mg curcumin nanomicelle and those in the placebo group took daily placebo for 10 weeks. Semen analysis, anthropometric, physical activity assessments, total antioxidant capacity, malondialdehyde, inflammatory factors, and reproductive hormones were measured at the baseline and at the end of the study. At the end of study, statistically significant differences were seen in the total sperm count, sperm concentration, and motility in the intervention group to the control group. In treatment group, the total sperm count, sperm concentration, and motility levels were also statistically increased at the end of study compared to the baseline values. Curcumin nanomicelle supplementation also resulted in a statistically significant improvement in plasma levels of total antioxidant capacity, malondialdehyde, C-reactive protein, and tumor necrosis factor a in comparison to the placebo. Medical therapy of asthenoteratospermia with curcumin nanomicelle supplement could improve quality of semen parameters. However, further investigation is suggested in this regard.

76 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023166
2022338
2021229
2020245
2019202
2018233