Topic
Semen analysis
About: Semen analysis is a research topic. Over the lifetime, 4909 publications have been published within this topic receiving 143225 citations.
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TL;DR: The presence of Ureaplasma in the male genital tract did not affect ejaculate volume, motility, viability, or morphology, and the longevity of sperm as evaluated by sperm motility and viability at different intervals of time was also not influenced by the presence of the virus.
56 citations
TL;DR: Low levels of cadmium accumulation in semen may contribute to male infertility by reducing sperm quality.
56 citations
TL;DR: Using means of multiple samples before and following therapeutic intervention will not prevent regression towards the mean, only reduce its magnitude, thus, placebos are essential in the evaluation of treatments for male infertility.
Abstract: Regression towards the mean was demonstrated in semen analyses from 216 donors for artificial insemination by selecting those with low sperm concentration (less than 40 X 10(6)/ml), low motility (less than 50%) or low motility index (less than 120) in the first test. For each characteristic, the result was significantly higher in the second test, the means for first and second tests being, for sperm concentration 28 and 56 million per ml (n = 14, P less than 0.01), for motility 42 and 55% (n = 14, P less than 0.01) and for the motility index 95 and 131 (n = 24, P less than 0.001). Regression towards the mean occurs whenever extremes of the range of a variable and selected for re-measurement. Many of the current treatments for oligospermia and asthenospermia have been promoted because semen quality improved during uncontrolled studies in which this phenomenon may have been operative. Using means of multiple samples before and following therapeutic intervention will not prevent regression towards the mean, only reduce its magnitude. Thus, placebos are essential in the evaluation of treatments for male infertility.
56 citations
TL;DR: Simultaneous measurement of both FSH and inhibin B identified more cases with oligozoospermia than either hormone alone and the indirect mixed antiglobin reaction (MAR) test result appears accurate in identifying subfertility.
56 citations
TL;DR: Fertilization with spermatozoa without head vacuoles yielded higher number of morphologically normal zygotes, higher blastocyst rate and smaller proportion of arrested embryos than spermutozoa with vacUoles and other head defects, suggesting IMSI is a method of choice in patients with teratozoospermia.
Abstract: This prospective randomized study investigated whether intracytoplasmic sperm injection (ICSI) outcome can be improved with sperm preselection under ×6000 magnification and intracytoplasmic morphologically selected sperm injection (IMSI) in patients with teratozoospermia and characterized embryo development and quality regarding sperm morphology and presence of head vacuoles. Couples with isolated teratozoospermia were divided into two groups: IMSI group (n=52) and ICSI group (n=70) and fertilization, blastocyst and clinical pregnancy rates were compared. Oocytes from 30 randomly chosen patients from the IMSI group were injected with spermatozoa that had been previously classified under ×6000 magnification into four classes according to the number and size of vacuoles in the head and then cultured separately. Pronuclear morphology, embryo development and blastomere viability were estimated to investigate the influence of sperm morphology, especially vacuoles, on embryo developmental capacity. A significantly higher clinical pregnancy rate was achieved in the IMSI group compared with the ICSI group (48% versus 24%, P<0.05). Fertilization with spermatozoa without head vacuoles yielded higher number of morphologically normal zygotes, higher blastocyst rate and smaller proportion of arrested embryos than spermatozoa with vacuoles and other head defects. IMSI is a method of choice in patients with teratozoospermia.
56 citations