Topic
Semen analysis
About: Semen analysis is a research topic. Over the lifetime, 4909 publications have been published within this topic receiving 143225 citations.
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TL;DR: Elevated male age, after correcting for female age, was not related to lower fertilisation rates or significant decreases in the chance for a healthy baby at home, and Logistic regression analysis did not reveal any male age‐related influences on sperm parameters like concentration, motility or morphology.
Abstract: In the human, male ageing results in reproductive hormonal and cellular changes that can influence semen quality (volume, motility, concentration and morphology) and ultimately result in a reduced fertilising capacity and a longer 'time to pregnancy' for ageing men as well as an increased risk for miscarriage. This prospective cohort study of 278 patients undergoing a first in vitro fertilisation or intracytoplasmic sperm injection treatment was undertaken to examine whether patient's age was reflected in sperm motility, concentration, morphology as well as in DNA fragmentation (DFI) and immature chromatin (unprocessed nuclear proteins and/or poorly condensed chromatin) as measured by the sperm chromatin structure assay. This study also investigated the possible influence of male age (after correcting for female age) on their fertilising capacity, on obtaining a pregnancy and a healthy baby at home. Logistic regression analysis did not reveal any male age-related influences on sperm parameters like concentration, motility or morphology. No significant male age-related increase in DFI or immature chromatin was demonstrable for these patients. Elevated male age, after correcting for female age, was not related to lower fertilisation rates or significant decreases in the chance for a healthy baby at home.
79 citations
TL;DR: Serum inhibin B level seems to be more accurate than serum FSH level in prediction of the presence of testicular spermatozoa in patients with nonobstructive azoospermia.
79 citations
TL;DR: No predictive tools for post-treatment fertility were found and, therefore, every patient with a lymphoma should have his semen cryopreserved at diagnosis, and the post- treatment sperm outcome was better in patients treated with local irradiation than in those who did not undergo irradiation.
Abstract: distinct, the former being the most common type of lymphoma during the reproductive period of life, with a peak incidence patients with non-Hodgkin's lymphoma or with Hodgkin's may be irreversible, but even if reversed, repair may take as disease during the years 1987-1997 who were referred for long as 20 years (Marmor and Duyck, 1995). New treatment semen cryopreservation. Pretreatment semen analysis, and regimens have increased patient survival substantially, so that hormonal profile were recorded at diagnosis and at least more patients at the reproductive age are living and are 1 year after completion of the treatment, and compared. confronted with infertility. Medical records for disease type, disease stage and treat- Semen cryopreservation is an element of management of ment protocols were related to long-term sperm outcome. lymphoma patients. This is due to the growing awareness of Hormonal concentrations were not predictive of post- physicians and patients themselves regarding the potentially treatment sperm concentration. In patients with localized devastating effect of the disease and its treatment on spermato- disease, initial sperm concentration and motility tended to genesis and future fertility. Patients who had a lymphoma were be preserved, compared with patients with widespread referred to our institute for semen cryopreservation before disease (P 0.016). In Hodgkin's disease patients, treat- commencing treatment. Previously, we studied the effect of ment with the adriamycin, bleomycin, vinblastine and lymphomas on spermatogenesis and assessed pretreatment dacarbazine (ABVD) protocol was superior to the mechlor- sperm quality (Botchan et al., 1997). The present study etamine, vincristine, procarbazine and prednisone with was conducted to determine the factors, either the disease ABV protocol regarding germinal toxicity (P 0.0008). characteristics themselves, or different treatment protocols, The post-treatment sperm outcome was better in patients directly related to semen concentration and motility deteriora- treated with local irradiation than in those who did not tion. In this study we assessed pre- and post-treatment sperm undergo irradiation (P 0.0027). No predictive tools for quality, reflected by sperm motility and concentration. Patients post-treatment fertility were found and, therefore, every were categorized by their disease (HD or NHL), disease stage patient with a lymphoma should have his semen cryopre- and treatment. Staging included distinction between patients served at diagnosis. with and without systemic symptoms: fever, weight loss and
79 citations
TL;DR: The observed differences in signaling and metabolic pathways between the infertile sperm and the normal fertile spermatozoa have implications in sperm motility, capacitation, acrosomal reaction and sperm-oocyte communication.
79 citations
TL;DR: It is indicated that sperm from men with a history of iRPL have a higher percentage of DNA damage as compared to control group, and this can explain pregnancy loss in these patients.
Abstract: Purpose
Standard semen parameters are poor predictors of fertility potential. To date, apart from, paternal karyotyping sperm factors are not evaluated in recurrent pregnancy loss (RPL), only recent studies have emphasized the role of sperm factors in early embryonic development as sperm transcribes genes critical for early embryonic development. Sperm DNA integrity is useful diagnostic and prognostic marker and has clinical implications in idiopathic recurrent pregnancy loss (iRPL) following spontaneous conception. The aim of this study was to assess DNA integrity in cases experiencing iRPL following spontaneous conception.
79 citations