Topic
Serum albumin
About: Serum albumin is a research topic. Over the lifetime, 16337 publications have been published within this topic receiving 516395 citations. The topic is also known as: blood albumin & ANALBA.
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TL;DR: The results indicate that serum albumins are capable of transporting retinoids in vitro and in vivo, and the complexation of bovine serum albumin with retinol and retinoic acid at physiological conditions is reported.
145 citations
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TL;DR: It is found that protein hydration correlates strongly with the sum of the polar residues minus the amides; amides apparently inhibit water binding.
145 citations
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TL;DR: The findings suggest that animal monoclonal antibodies specific for cow's milk proteins are able to recognize the major part of milk proteins from mammals bred in Mediterranean countries (sheep, goat, and buffalo); weak cross-reactivity was observed with milk proteins with mares and donkeys.
Abstract: Background Cross-reactivity between food allergens occurs when they share part of their amino acid sequence, or when their three-dimensional molecular structure causes them to have a similar capacity to bind specific antibodies. Objectives To review data from our laboratory on cross-reactivity between mammalian proteins (milk and meat allergens). Methods Studies used immunoelectrophoresis (sodium dodecyl sulfate-polyacrylamide gel electrophoresis/polyacrylamide gel electrophoresis and immunoblotting), and animal monoclonal antibodies. Results The findings suggest that animal monoclonal antibodies specific for cow's milk proteins are able to recognize the major part of milk proteins from mammals bred in Mediterranean countries (sheep, goat, and buffalo); weak cross-reactivity was observed with milk proteins from mares and donkeys. None of the antibodies used in our studies reacted with proteins from an exotic mammalian species: the camel. Similar cross-reactions were found with human circulating immunoglobulin E from children allergic to milk. With regard to beef allergy, monoclonal antibodies specific for bovine serum albumin cross-reacted only with ovine serum albumin, whereas the number of sera from allergic children able to recognize other mammalian serum albumins depended directly on the closeness of phylogenetic relationship between animal species and inversely on the percent identity with human serum albumin in the main epitopic sequence. Conclusion An area of heterogeneity between animal and human species in a critical amino acid sequence (epitope) of an allergen can determine the degree of immunogenic activity.
144 citations
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TL;DR: The relative fluorescence intensity of the paclitaxel-bound HSA decreased, suggesting that perturbation around the Trp 214 residue took place, and this was confirmed by the destabilization of the warfarin binding site, which includes Trp214, and high affinity bilirubin binding sites located in subdomain IIA.
144 citations
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TL;DR: In otherwise healthy subjects who were severely nutrient-deprived due to poor access to food or unwillingness to eat, serum albumin and prealbumin levels are not "markers of nutritional status" and should not be assumed to reflect nutritional deprivation.
144 citations