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Serum albumin

About: Serum albumin is a research topic. Over the lifetime, 16337 publications have been published within this topic receiving 516395 citations. The topic is also known as: blood albumin & ANALBA.


Papers
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Journal ArticleDOI
TL;DR: High affinity binding of TCs with BSA signifies drug stability, however, excessive binding at higher TC concentrations in combination with Cu (II) induces conformational change in protein structure, which may exert detrimental effect on cellular protein.

126 citations

Journal ArticleDOI
TL;DR: It is concluded that changes in the rate of protein degradation are the single most important factor determining the increase in protein content during liver compensatory growth.

126 citations

Journal ArticleDOI
TL;DR: These findings suggest that the trafficking of anandamide from the plasma membrane to the internal compartments of a cell occur via a nonvesicular mechanism mediated by cytosolic carriers.

126 citations

Journal ArticleDOI
TL;DR: Three distinct types of behaviour concerning the adsorption of albumin on to metal surfaces were identified and it is suggested that electrostatic forces could be responsible for this phenomenon.

126 citations

Journal ArticleDOI
TL;DR: Changes in serum lipoproteins studied in twelve patients with untreated uncomplicated nephrotic syndrome were strictly correlated with the concentration of serum albumin and were more pronounced in the patients with serumalbumin < 20 g l‐1.
Abstract: . The quantitative and qualitative changes of serum lipoproteins have been studied in twelve patients with untreated uncomplicated nephrotic syndrome. The lipoprotein disorders found in these patients were characterized by an elevation of VLDL (d < 1.006 g ml-1), LDL (d 1.006–1.019 g ml-1) and LDL2 (d 1.019–1.063 g ml-1) and a diminution of HDL2 (d 1.063–1.125 g ml-1). These changes were strictly correlated with the concentration of serum albumin and were more pronounced in the patients with serum albumin < 20 g l-1. The study of the relationship among the concentrations of the various lipoprotein classes indicated that (i) the levels of VLDL and LDL1 were reciprocally related to that of the high density lipoproteins and (ii) the level of LDL2 rose with the moderately increased VLDL and LDL1 but at the high concentrations of VLDL and LDL1 observed in the severe nephrotic syndrome it did not show any further increase, suggesting a defect in the conversion of VLDL to LDL2. The nephrotic syndrome was associated with marked changes in the composition of all lipoprotein fractions which were found to contain more phospholipid but less protein than normal. Major changes in composition were observed in VLDL and LDL1 which were rich in esterified cholesterol and phopholipids and had an esterified cholesterol: triglyceride molar ratio (CE/TG) higher than the corresponding fractions of the control subjects. Furthermore, CE/TG ratio in these fractions increased as their serum concentration increased. These observations indicate that in severe, untreated uncomplicated nephrotic syndrome there is a progressive accumulation of d < 1.019 g ml-1 lipoproteins rich in esterified cholesterol. Chemically these resemble VLDL and chylomicron remnants and are possibly related to some defect in the conversion of VLDL to LDL2.

126 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202379
2022208
2021267
2020296
2019295
2018323