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Serum albumin

About: Serum albumin is a research topic. Over the lifetime, 16337 publications have been published within this topic receiving 516395 citations. The topic is also known as: blood albumin & ANALBA.


Papers
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Journal ArticleDOI
TL;DR: The accurate and full basic data in the work is beneficial to clarifying the binding mechanism of TC with HSA in vivo and understanding its effect on protein function during the blood transportation process.

274 citations

Journal ArticleDOI
TL;DR: Kratz et al. as discussed by the authors proposed a macromolecular prodrug strategy for improved cancer chemotherapy based on two features: rapid and selective binding of thiol-reactive prodrugs to the cysteine-34 position of endogenous albumin after intravenous administration and release of the albumin-bound drug in the acidic environment at the tumor site due to the incorporation of an acidsensitive bond between the drug and the carrier.
Abstract: We have recently proposed a macromolecular prodrug strategy for improved cancer chemotherapy based on two features (Kratz, F.; et al. J. Med. Chem 2000, 43, 1253−1256.): (a) rapid and selective binding of thiol-reactive prodrugs to the cysteine-34 position of endogenous albumin after intravenous administration and (b) release of the albumin-bound drug in the acidic environment at the tumor site due to the incorporation of an acid-sensitive bond between the drug and the carrier. To investigate this therapeutic strategy in greater depth, four (maleinimidoalkanoyl)hydrazone derivatives of doxorubicin were synthesized differing in the length of the aliphatic spacer (1, −(CH2)2−; 2, −(CH2)3−; 3, −(CH2)5−; 4, −(CH2)7−). The albumin-binding doxorubicin prodrugs, especially the (6-maleimidocaproyl)hydrazone derivative of doxorubicin (3), are rapidly and selectively bound to the cysteine-34 position of endogenous albumin. 3 was distinctly superior to the parent compound doxorubicin in three animal tumor models (R...

274 citations

Journal ArticleDOI
TL;DR: PGE2 stimulation of bone resorption increased linearly with the logarithm of the medium concentration over the range of 10(-9)M to 10(-5)M, then decreased at higher concentrations, but prostaglandins of the E series were 10- to 100- fold more potent than F, A or B prostaglandsins.

273 citations

Journal ArticleDOI
TL;DR: In this article, photolysis using ultraviolet light and graft polymerization of hydrophilic monomers onto the membrane surface was used to create more hyrophilic and lower fouling membrane surfaces.

273 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202379
2022208
2021267
2020296
2019295
2018323