Topic
Serum albumin
About: Serum albumin is a research topic. Over the lifetime, 16337 publications have been published within this topic receiving 516395 citations. The topic is also known as: blood albumin & ANALBA.
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TL;DR: The result of transcytosis across the blood-brain barrier (BBB) coculture and brain delivery in mice proved that the increase of surface CBSA density of the nanoparticle enhanced the BBB permeability-surface area but decreased blood AUC.
189 citations
188 citations
TL;DR: Structural analysis showed that curcumin and genistein bind HSA via polypeptide polar groups with overall binding constants of K(curcumin) and K(genistein) and the HSA conformation was altered by pigment complexation with reduction of alpha-helix and increase of random coil and turn structures suggesting a partial protein unfolding.
188 citations
TL;DR: The results show that a considerable fraction of albumin‐bound tryptophan is stripped from albumin sites during passage, that uptake is concentration‐dependent, and that amino acid competition for carrier sites is quantitatively the most important factor in regulating tryPTophan uptake into brain.
Abstract: — In the present study we examine the influence of pH, palmitate, and neutral amino acids on the passage of tryptophan from blood into brain during a single capillary pass, and on the partitioning of tryptophan between free and albumin-bound forms. The results show that a considerable fraction of albumin-bound tryptophan is stripped from albumin sites during passage, that uptake is concentration-dependent, and that amino acid competition for carrier sites is quantitatively the most important factor in regulating tryptophan uptake into brain. The interaction between tryptophan concentration, tryptophan binding, and competing amino acids is of considerable influence on brain serotonin biosynthesis.
188 citations
TL;DR: The results are interpreted as broadly supporting the previous proposal that lipid exchange between albumin and sperm cells is implicated in sperm capacitation in vitro and compatible with the idea that a decreased cholesterol/phospholipid ratio in the sperm plasma membrane facilitates this transformation.
187 citations