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Serum albumin

About: Serum albumin is a research topic. Over the lifetime, 16337 publications have been published within this topic receiving 516395 citations. The topic is also known as: blood albumin & ANALBA.


Papers
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Journal ArticleDOI
TL;DR: Results indicate the pathway of albumin secretion to be: rough membranes-smooth membranes-Golgi bodies-blood, which could represent albumin in temporarily quiescent membrane channels or in pinocytotic vesicles.

162 citations

Journal ArticleDOI
TL;DR: The movement of intravitreal nanoparticles depended on both nanoparticles surface charge and retinal injury, and the anionic HSA-NP is a promising drug or gene delivery carrier to the sub-retinal space and RPE.
Abstract: Purpose To investigate the movement of intravitreally injected human serum albumin nanoparticles (HSA-NP) with respect to nanoparticle surface charge and retinal injury.

162 citations

Journal ArticleDOI
TL;DR: It is concluded that PTU and MMI have similar placental transfer kinetics and there was no significant difference between drugs or drug doses and no effect of addition of albumin.
Abstract: Propylthiouracil (PTU) is widely believed to cross the placenta less freely than methimazole (MMI) and is therefore regarded as the preferred drug for treatment of hyperthyroidism in pregnancy. Clinical studies comparing the two drugs show, however, no differences in maternal or fetal thyroid function. We investigated transfer from the maternal to the fetal circuit in the isolated perfused term human placental lobule of low and high doses of PTU (4 micrograms/mL and 40 micrograms/mL) and MMI (1.5 micrograms/mL and 15 micrograms/mL) in protein-free perfusate and low doses of both drugs with addition of 40 g/L of bovine albumin. Both drugs readily crossed the placenta, reaching equilibrium in all experiments in about 2 h. Drug concentrations in the two circuits fitted a two compartmental model. Transfer kinetics for the two drugs were similar, nonsaturable, and unaffected by addition of albumin. Clearances (mL.min-1.g-1, means +/- SD) of PTU from maternal to fetal circuits were: 0.229 +/- 0.110, 0.216 +/- 0.065, and 0.170 +/- 0.032; and for transfer of MMI: 0.165 +/- 0.025, 0.232 +/- 0.153, and 0.174 +/- 0.009 (for low doses without, low doses with, and high doses without albumin, respectively). Clearances of PTU from fetal to maternal circuits were: 0.147 +/- 0.072, 0.109 +/- 0.014, and 0.116 +/- 0.028; and for transfer of MMI: 0.095 +/- 0.029, 0.122 +/- 0.088, and 0.12 +/- 0.005 (in the same experiments). There was no significant difference between drugs or drug doses and no effect of addition of albumin. We conclude that PTU and MMI have similar placental transfer kinetics.

161 citations

Journal ArticleDOI
TL;DR: The amount of albumin in the intracellular albumin pool was observed to reach its normal level even before the circulating albumin level was restored, signifying that hypoalbuminemia can elicit increased synthesis without maintaining a decrease in the intrahepatic pool.

161 citations

Journal ArticleDOI
TL;DR: This review focuses on the combination of biochromatography and circular dichroism as an effective approach for the characterization of albumin binding sites and their enantioselectivity.

161 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202379
2022208
2021267
2020296
2019295
2018323