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Shikimic acid

About: Shikimic acid is a research topic. Over the lifetime, 961 publications have been published within this topic receiving 27110 citations. The topic is also known as: 3alpha,4alpha,5beta-trihydroxy-1-cyclohexene-1-carboxylic acid & [3R-(3alpha,4alpha,5beta)]-3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid.


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Book
01 Jan 1997
TL;DR: This book discusses primary and Secondary Metabolism, primary and secondary metabolism of Acids, Bases, and Ions, and some Vitamins Associated with the Construction Mechanisms.
Abstract: About this book and how to use it Secondary metabolism: The building blocks and construction mechanisms The acetate pathway: Fatty acids and polyketides The shikimate pathway: Aromatic amino acids and phenylpropanoids The mevalonate and deoxyxylulose phosphate pathways: Terpenoids and Steroids: Alkaloids Peptides, proteins and other amino acid derivatives Carbohydrates Index

1,156 citations

Journal ArticleDOI
TL;DR: The broadspectrum herbicide glyphosate inhibits the enzymatic conversion of shikimic acid to anthranilic acid in a cell-free extract of Aerobacter, aerogenes 50% at 5 to 7 μM concentrations.

985 citations

Journal ArticleDOI
TL;DR: The pathway organization and the transcriptional/posttranscriptional regulation of the AAA biosynthetic network is summarized and the current limited knowledge of the subcellular compartmentalization and the metabolite transport involved in the plant AAA pathways is identified.
Abstract: L-tryptophan, L-phenylalanine, and L-tyrosine are aromatic amino acids (AAAs) that are used for the synthesis of proteins and that in plants also serve as precursors of numerous natural products, such as pigments, alkaloids, hormones, and cell wall components. All three AAAs are derived from the shikimate pathway, to which ≥30% of photosynthetically fixed carbon is directed in vascular plants. Because their biosynthetic pathways have been lost in animal lineages, the AAAs are essential components of the diets of humans, and the enzymes required for their synthesis have been targeted for the development of herbicides. This review highlights recent molecular identification of enzymes of the pathway and summarizes the pathway organization and the transcriptional/posttranscriptional regulation of the AAA biosynthetic network. It also identifies the current limited knowledge of the subcellular compartmentalization and the metabolite transport involved in the plant AAA pathways and discusses metabolic engineering efforts aimed at improving production of the AAA-derived plant natural products.

976 citations

Journal ArticleDOI
TL;DR: The Shikimate Pathway as mentioned in this paper is a metabolic tree with many branches, which is a tree-structured approach for the analysis of the human metabolic pathway. Critical Reviews in Biochemistry and Molecular Biology: Vol. 25, No. 5, pp 307-384.
Abstract: (1990). The Shikimate Pathway — A Metabolic Tree with Many Branche. Critical Reviews in Biochemistry and Molecular Biology: Vol. 25, No. 5, pp. 307-384.

682 citations

Journal ArticleDOI
25 Jun 1998-Nature
TL;DR: The shikimate pathway is an attractive target for herbicides and antimicrobial agents because it is essential in algae, higher plants, bacteria and fungi, but absent from mammals as discussed by the authors.
Abstract: Parasites of the phylum Apicomplexa cause substantial morbidity, mortality and economic losses, and new medicines to treat them are needed urgently. The shikimate pathway is an attractive target for herbicides and antimicrobial agents because it is essential in algae, higher plants, bacteria and fungi, but absent from mammals. Here we present biochemical, genetic and chemotherapeutic evidence for the presence of enzymes of the shikimate pathway in apicomplexan parasites. In vitro growth of Toxoplasma gondii, Plasmodium falciparum (malaria) and Cryptosporidium parvum was inhibited by the herbicide glyphosate, a well-characterized inhibitor of the shikimate pathway enzyme 5-enolpyruvyl shikimate 3-phosphate synthase. This effect on T. gondii and P. falciparum was reversed by treatment with p-aminobenzoate, which suggests that the shikimate pathway supplies folate precursors for their growth. Glyphosate in combination with pyrimethamine limited T. gondii infection in mice. Four shikimate pathway enzymes were detected in extracts of T. gondii and glyphosate inhibited 5-enolpyruvyl shikimate 3-phosphate synthase activity. Genes encoding chorismate synthase, the final shikimate pathway enzyme, were cloned from T. gondii and P. falciparum. This discovery of a functional shikimate pathway in apicomplexan parasites provides several targets for the development of new antiparasite agents.

473 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202331
202242
202115
202017
201924
201826