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Signal transduction

About: Signal transduction is a research topic. Over the lifetime, 122628 publications have been published within this topic receiving 8209258 citations. The topic is also known as: GO:0007165.


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Journal ArticleDOI
TL;DR: In this article, the authors describe a system of rather different cellular components assembled to guarantee a specific and successful process of signal transduction between the signal and the gene, which are evolutionarily conserved and ubiquitously distributed amongst living organisms.
Abstract: The development and life-time of multicellular eukaryotic organisms represents a complex interplay of numerous proliferation and differentiation events that proceed in a highly ordered manner. As a prerequisite for those events, cells must respond to extracellular signals with a specific set of mechanisms that regulate or modulate gene expression. Between the signal and the gene, a system of rather different cellular components is assembled to guarantee a specific and successful process of signal transduction. Pathways of signal transduction, though differing remarkably in their complexity and in the use of cellular components, seem to obey certain principles which are evolutionarily conserved and ubiquitously distributed amongst living organisms. Extracellular signals, so-called ligands, either penetrate the cellular membrane or bind to the extracellular domain of receptors. Activated receptors as such, or in association with socalled transducers, are capable of activating effectors-either directly or by means of changing the amount or intracellular distribution of so-called second messengers. These second

1,229 citations

Journal ArticleDOI
TL;DR: Using multiparameter single-cell detection methods to investigate upstream signaling pathways and ensuing cell cycle checkpoint responses in human fibroblasts concluded that stable arrest requires continuous signaling.

1,228 citations

Journal ArticleDOI
John Blenis1
TL;DR: Although this intracellular signal transduction pathway is extremely complex, conservation of many of its components has been observed in yeast, nematodes, Drosophila, and mammals, Thus, these signaling proteins may participate in the regulation of a variety of cellular processes.
Abstract: An explosion of new information linking activation of cell surface signal initiators to changes in gene expression has recently emerged. The focus of much of this information has centered around the agonist-dependent activation of the mitogen-activated protein (MAP) kinases. Although this intracellular signal transduction pathway is extremely complex, conservation of many of its components has been observed in yeast, nematodes, Drosophila, and mammals. Thus, these signaling proteins may participate in the regulation of a variety of cellular processes.

1,225 citations

Journal ArticleDOI
TL;DR: There have been many advances in knowledge about different aspects of P2Y receptor signaling since the last review published by the International Union of Pharmacology subcommittee, and more receptor subtypes have been cloned and characterized and most orphan receptors deorphanized, so that it is now possible to provide a basis for a future subdivision of P 2Y receptor sub types.
Abstract: There have been many advances in our knowledge about different aspects of P2Y receptor signaling since the last review published by our International Union of Pharmacology subcommittee. More receptor subtypes have been cloned and characterized and most orphan receptors deorphanized, so that it is now possible to provide a basis for a future subdivision of P2Y receptor subtypes. More is known about the functional elements of the P2Y receptor molecules and the signaling pathways involved, including interactions with ion channels. There have been substantial developments in the design of selective agonists and antagonists to some of the P2Y receptor subtypes. There are new findings about the mechanisms underlying nucleotide release and ectoenzymatic nucleotide breakdown. Interactions between P2Y receptors and receptors to other signaling molecules have been explored as well as P2Y-mediated control of gene transcription. The distribution and roles of P2Y receptor subtypes in many different cell types are better understood and P2Y receptor-related compounds are being explored for therapeutic purposes. These and other advances are discussed in the present review.

1,225 citations

Journal ArticleDOI
TL;DR: This work has identified an alternative adaptor, designated Toll-interleukin 1 receptor domain (TIR)-containing adaptor molecule (TICAM)-1, that can physically bind the TIR domain of TLR3 and activate the IFN-β promoter in response to poly(I):poly(C).
Abstract: Human Toll-like receptor (TLR) 3 recognizes double-stranded (ds) RNA and induces production of interferon (IFN)-beta independent of the adaptor molecules MyD88 and TIRAP. Thus, another adaptor must exist that preferentially mediates TLR3-dependent production of IFN-beta. We have identified an alternative adaptor, designated Toll-interleukin 1 receptor domain (TIR)-containing adaptor molecule (TICAM)-1, that can physically bind the TIR domain of TLR3 and activate the IFN-beta promoter in response to poly(I):poly(C). Thus, dsRNA-TLR3-dependent production of IFN-beta is mediated mainly by TICAM-1. This TICAM-1-dependent pathway may have a role in other TLR-IFN-beta pathways, which form part of the MyD88-independent cellular immune response.

1,224 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20232,989
20225,166
20213,971
20204,179
20194,445
20184,585