Topic
Silica gel
About: Silica gel is a research topic. Over the lifetime, 22313 publications have been published within this topic receiving 325516 citations. The topic is also known as: Amorphous silica & Precipitated amorphous silica.
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TL;DR: In this article, the feasibility of using silica aerogels as oral drug delivery systems was investigated and it was demonstrated that for all three drugs investigated here, high loading of the aerogel could be achieved.
Abstract: The feasibility of silica aerogels as oral drug delivery systems was investigated. Silica aerogels were loaded with several drugs by adsorption from their solutions in supercritical CO2. It was demonstrated that for all three drugs investigated here, high loading of the aerogel could be achieved. The loaded aerogels were characterized by IR- and UV spectroscopy and X-ray diffraction in order to show that no degradation of the drugs occurred during the loading procedure. The release profiles of two drugs (ketoprofen and griseofulvin) from loaded aerogels were measured. It was found that the drugs adsorbed on hydrophilic silica aerogels dissolve faster than the corresponding crystalline drugs. This fact can be explained by both an increase in the specific surface area of the drug adsorbed on the aerogel and its non-crystallinity in this state. The influence of density and hydrophobicity of aerogels on both the adsorption and release of drugs were studied.
289 citations
TL;DR: In this paper, the authors used ESCA, IRRS, fluoric acid etching test, and sodium leaching test to evaluate the composition and the structure of these films.
Abstract: Silica film was deposited on the surface of soda lime silicate glass by immersing it in hydrofluosilicic acid solution supersaturated with silica gel at low temperature. The composition and the structure of these films were evaluated using ESCA, IRRS, fluoric acid etching test, and sodium leaching test, and they were compared with those of various silica films prepared by other methods. The results showed that these films made at low temperature had a dense structure and a great alkali barrier effect. By heat‐treatment, the structure of this film became denser, getting close to that of fused silica. It was also found that the degree of supersaturation and the solution temperature had a great influence on the deposition rate.
287 citations
TL;DR: The stability of APS in ethanol and that of mercaptopropyl-grafted silica (MPS) in water have been briefly considered and discussed with respect to practical applications of silica-based organic-inorganic hybrids, e.g., in separation science or in the field of electrochemical sensors.
283 citations
TL;DR: In this article, a method for the analysis of isomeric monoglycerides by thin-layer adsorption chromatography was developed for the separation of 1-and 2-monoglyceride.
Abstract: A method has been developed for the analysis of isomeric monoglycerides by thin-layer adsorption chromatography Isomeric monoglycerides are separated on silica gel impregnated with boric acid; a mixed solvent system is used The interaction of hydroxy compounds with boric acid allows the separation of 1- and 2-monoglycerides which cannot be resolved on silica gel alone In order to make the method quantitative, the resolved components are charred and their spot densities measured Glycerol, fatty acids, diglycerides, and triglycerides do not interfere The method does not induce isomerization
283 citations
TL;DR: The improved method involved production of silica aquagel by adding silicate solution to pH 1.5 hydrochloric, citric, or oxalic acid solutions until the pH 4.0 was reached and silica xerogels produced by the improved method had sodium content of 0.52% and 0.22%, respectively.
280 citations