Topic
Silica gel
About: Silica gel is a research topic. Over the lifetime, 22313 publications have been published within this topic receiving 325516 citations. The topic is also known as: Amorphous silica & Precipitated amorphous silica.
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TL;DR: The results showed that immobilized cells could be repeatedly used in the sorption process up to five times, and temperature did not have an influence on metal sorption, whereas an initial pH solution did.
182 citations
TL;DR: Gluco- and galactocerebrosides can be separated by thin-layer chromatography on Silica Gel G prepared with sodium borate solution instead of water by chloroform-methanol-water-15 M NH(4)OH 280:70:6:1.
182 citations
TL;DR: In this article, the authors examined the variables affecting the nucleation and crystallization of biological hydroxy carbonate apatite (HCA) on porous gel-silica substrates and found that texture is the critical variable with the rate of HCA formation increasing as pore size and pore volume increase.
Abstract: The variables affecting the nucleation and crystallization of biological hydroxy carbonate apatite (HCA) on porous gel-silica substrates are examined. Texture is the critical variable with the rate of HCA formation increasing as pore size and pore volume increase, with pore sizes >2 nm required to achieve rapid kinetics (4–6 days) of fully crystallized HCA. The concentration of silanol groups on the silica surface does not control the rate of HCA formation although metastable surface defects, such as trisiloxane rings, may be involved in HCA nucleation.
181 citations
181 citations
TL;DR: It is suggested that silica xerogel is a promising controlled release material for the treatment of bone infections.
Abstract: Room temperature processed silica sol-gel (xerogel) was investigated as a novel controlled release carrier of antibiotics (vancomycin). Xerogel characteristics, in vitro release properties, and bactericidal efficacy of the released antibiotic were determined. The xerogel/vancomycin composite showed a long-term sustained release (up to 6 weeks). In addition, bactericidal efficacy of released vancomycin was retained. The kinetics of release and the amount released were dose dependent. The initial, first-order release was followed by a near-zero-order release. The time to transition from the first- to zero-order release increased with vancomycin load (from 2 to 3 weeks with load increase from 2.2 to 11.1 mg/g). Regardless of the load, about 70% of the original vancomycin content was released by the transitional point, and the cumulative release after 6 weeks of immersion was about 90%. This study, combined with other reports documenting biocompatibility and controlled resorbability of the xerogel/drug composite in vivo, suggests that silica xerogel is a promising controlled release material for the treatment of bone infections.
181 citations