Topic
Sister chromatid exchange
About: Sister chromatid exchange is a research topic. Over the lifetime, 3187 publications have been published within this topic receiving 90029 citations. The topic is also known as: replication-born DSB repair by SCE & GO:1990414.
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TL;DR: DPCs, SCEs, and HFCs are reliable biomarkers for monitoring workers exposed to lead and clearly indicate health effects from occupational exposure to lead.
Abstract: Levels of sister chromatid exchanges (SCEs), high-SCE frequency cells (HFCs), DNA-protein cross-links (DPCs), blood lead (BLL), and zinc protoporphyrin (ZPP) were measured in peripheral blood from three groups. The lead workers were divided into two groups: a high BLL group (≥15μg/dl) and a low BLL group ( 15 μg/dl, of which, 3 exceeded current exposure limits (≥40 μg/dl). The BLL levels of all 11 controls were <15 μg/dl. The average SCE and DPC values for the workers were 6.1 SCEs/cell and 1.9%, which were significantly higher ( P < 0.01, Wilcoxon’s test) than the value of 5.2 SCEs/cell and 1.1% for the control subjects. Lead workers had significantly higher BLL and ZPP levels than did the controls. Statistically significant increases in DPCs, SCEs, and HFCs were observed for the high-BLL group compared with the control group. The results of this study suggest that DPCs, SCEs, and HFCs are reliable biomarkers for monitoring workers exposed to lead and clearly indicate health effects from occupational exposure to lead.
30 citations
TL;DR: Combinations of oxygen radical scavengers and antioxidants significantly reduced the number of sister-chromatid exchanges in Chinese hamster ovary cells exposed to human phagocytes stimulated to generate oxygen radicals.
Abstract: Combinations of oxygen radical scavengers and antioxidants significantly reduced the number of sister-chromatid exchanges in Chinese hamster ovary cells exposed to human phagocytes stimulated to generate oxygen radicals. When vitamin E was combined with these antioxidants, no increase in sister-chromatid exchanges was observed compared to controls.
30 citations
TL;DR: The results suggest that menthol does not have a chromosomal-damaging effect in human lymphocyte cultures and does not alter the SCE frequency in human chromosomes.
30 citations
TL;DR: Because the analysis revealed that each of the cytogenetic assays responds to a different set of structural features associated with carcinogenicity, it can be concluded that the assays can be included in a battery of tests to improve predictivity.
Abstract: Two independent analyses were carried out to compare the induction of sister chromatid exchanges and of chromosomal aberrations as predictors of carcinogenicity. Using both a classical and a Bayesian approach, as well as by analysis of the structural fragments generated by CASE, an artificial intelligence system, it is included that individually neither of these tests is a satisfactory predictor of carcinogenicity. However, because the analysis revealed that each of the cytogenetic assays responds to a different set of structural features associated with carcinogenicity, it can be concluded that the assays can be included in a battery of tests to improve predictivity.
30 citations