Topic
Sister chromatid exchange
About: Sister chromatid exchange is a research topic. Over the lifetime, 3187 publications have been published within this topic receiving 90029 citations. The topic is also known as: replication-born DSB repair by SCE & GO:1990414.
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TL;DR: There was no difference in the SCE rate between smokers and nonsmokers, nor was there any difference between heavy and light smokers.
Abstract: The incidence of sister chromatid exchanges in smokers and nonsmokers was investigated. There was no difference in the SCE rate between smokers and nonsmokers, nor was there any difference between heavy (>10 per day) and light (<10 per day) smokers.
62 citations
TL;DR: The inducibility of SCE with many kinds of heavy-metal ions including suspected carcinogens such as As, Cr, Ni and others is examined.
61 citations
TL;DR: Results indicate that human lymphocytes cells and plants cells (Allium cepa) have a very sensitive cellular response to the mycotoxin fumonisin B(1) as observed at the highest concentrations.
61 citations
TL;DR: It is indicated that cadmium, lead and zinc can induce micronucleated cells, SCEs and sperm abnormalities in Algerian mice and that the clastogenic potential is dependent on the time of exposure and the interaction between the three elements, confirming the environmental damage that may result from the simultaneous action of several metals.
Abstract: As a consequence of human activities, large amounts of cadmium, lead and zinc are released in the environment, often simultaneously. The aim of this study was to investigate under experimental conditions the DNA damage induced in Algerian mice (Mus spretus) exposed to cadmium (Cd), lead (Pb) and zinc (Zn) separately, or in selected combinations. Three cytogenetic end points were considered: the frequencies of micronucleated cells (MN) and sister chromatid exchange (SCE) in the bone marrow and the frequency of sperm abnormalities. Mice were treated by intraperitoneal (i.p.) injections with 5 or 10 doses of aqueous solutions of cadmium acetate, lead acetate and zinc acetate in concentrations corresponding to 1/10 of the LD50, respectively, 21.5, 0.46 and 1.5 mg/kg bw. The control groups were injected in the same way with distilled water. With only one exception (Cd + Zn group treated with 5 doses), the results show a significant increase of MN in all groups for both treatments (5 and 10 doses). Similarly, the results concerning the SCE revealed a statistically significant increase in all treated animals, with the exception of the Zn group treated with 5 doses. The number of sperm abnormalities was significantly higher in animals treated with 5 doses, except in the group Pb + Zn. In animals treated with 10 doses the number of sperm abnormalities was always statistically higher compared with controls. This study indicates that cadmium, lead and zinc can induce MN, SCEs and sperm abnormalities in Algerian mice and that the clastogenic potential is dependent on the time of exposure and the interaction between the three elements, confirming the environmental damage that may result from the simultaneous action of several metals. Most relevant is the toxic potential for Zn, related with the dose, which may compromise its protective effect against other metal contaminations, such as cadmium.
61 citations
TL;DR: Two pyrethroid insecticides, cypermethrin and fenvalerate, were tested for their ability to induce chromosome structural aberrations and sister chromatid exchanges in cultured human peripheral blood lymphocytes.
Abstract: Two pyrethroid insecticides, cypermethrin and fenvalerate, were tested for their ability to induce chromosome structural aberrations and sister chromatid exchanges in cultured human peripheral blood lymphocytes. Fenvalerate, but not cypermethrin, increased the frequencies of chromosome-type aberrations and sister chromatid exchanges. In addition, both pyrethroids affected the cell cycle causing a decrease in the proliferative rate index at concentrations greater than 10 micrograms/ml.
61 citations