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Sleep disorder

About: Sleep disorder is a research topic. Over the lifetime, 19380 publications have been published within this topic receiving 884281 citations. The topic is also known as: somnipathy & non-organic sleep disorder.


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Journal ArticleDOI
TL;DR: It is concluded that while sleep/wake patterns are significantly disturbed in AD, this phenomenon is not diagnostically useful for discrimination of mild stage AD.
Abstract: We examined the ability of sleep/wake measures to discriminate 45 control subjects from 44 mild Alzheimer's disease (AD) patients. Sleep fragmentation was observed as indicated by significant increases in time awake (37-52%) and number of awakenings (31-36%) during the night as compared to controls. Further, slow wave sleep (SWS) was significantly reduced (22%) in AD patients relative to controls. These findings are consistent with our earlier observations of increased wakefulness and decreased SWS in mild-moderate, moderate-severe, and severe stage AD patients. However, when we used these sleep/wake stage measures in discriminant analyses to classify the current AD subjects vs control subjects, the analyses failed to confirm our earlier high classification rate (90%). The present groups were discriminated at overall classification rates of only 63-67%. We conclude that while sleep/wake patterns are significantly disturbed in AD, this phenomenon is not diagnostically useful for discrimination of mild stage AD.

200 citations

Journal ArticleDOI
TL;DR: In this paper, the authors examined the relationship between job strain and sleep quality in a sample of primary and secondary school teachers and assessed whether the relationship was mediated or moderated by an individual's inability to "switch-off" from work-related issues during leisure time.
Abstract: The objectives of this study were, firstly, to examine the association between job strain and sleep quality in a sample of primary and secondary school teachers and, secondly, to assess whether the relationship between job strain and sleep quality is mediated or moderated by an individual's inability to "switch-off" from work-related issues during leisure time. School teachers (N= 143) completed an hourly record of their work-related thoughts over a workday evening between 5 p.m. and bedtime, and then rated their sleep quality the following morning. Individuals were classified as reporting high (n=46) or low (n=52) job strain using predetermined cut-off scores. Consistent with previous research, the results showed that both groups demonstrated a degree of unwinding and disengagement from work issues over the evening. However, compared to the low job strain group, the high job strain teachers took longer to unwind and ruminated more about work-related issues, over the whole evening, including bedtime. There was no difference in total sleep time between the groups, but high job strain individuals reported poorer sleep quality compared to low job strain individuals. With respect to the second objective, across the whole sample (N= 143), work rumination and job strain were significantly correlated with sleep quality, but work rumination was not found to mediate, or moderate the relationship between job strain and sleep quality. It was speculated that the initial low contribution of job strain to sleep quality (r = -.18) may have contributed to this null finding. The current findings may have implications for how we assess and manage sleep disturbance in stressed workers.

200 citations

Journal ArticleDOI
TL;DR: The sleep phenotype of HD includes insomnia, advanced sleep phase, periodic leg movements, REM sleep behavior disorders, and reduced REM sleep but not narcolepsy.
Abstract: Background Sleep disorders including insomnia, movements during sleep, and daytime sleepiness are common but poorly studied in Huntington disease (HD). Objective To evaluate the HD sleep-wake phenotype (including abnormal motor activity during sleep) in patients with various HD stages and the length of CAG repeats. Because a mild hypocretin deficiency has been found in the brains of some patients with HD (hereinafter referred to as HD patients), we also tested the HD patients for narcolepsy. Design and Patients Twenty-five HD patients (including 2 premanifest carriers) underwent clinical interview, nighttime video and sleep monitoring, and daytime multiple sleep latency tests. Their results were compared with those of patients with narcolepsy and control patients. Results The HD patients had frequent insomnia, earlier sleep onset, lower sleep efficiency, increased stage 1 sleep, delayed and shortened rapid eye movement (REM) sleep, and increased periodic leg movements. Three HD patients (12%) had REM sleep behavior disorders. No sleep abnormality correlated with CAG repeat length. Reduced REM sleep duration (but not REM sleep behavior disorders) was present in premanifest carriers and patients with very mild HD and worsened with disease severity. In contrast to narcoleptic patients, HD patients had no cataplexy, hypnagogic hallucinations, or sleep paralysis. Four HD patients had abnormally low ( Conclusions The sleep phenotype of HD includes insomnia, advanced sleep phase, periodic leg movements, REM sleep behavior disorders, and reduced REM sleep but not narcolepsy. Reduced REM sleep may precede chorea. Mutant huntingtin may exert an effect on REM sleep and motor control during sleep.

200 citations

Journal ArticleDOI
01 Jul 2001-Chest
TL;DR: There may be functional, rather than anatomic, differences in the upper airway between premenopausal and postmenopausal women, which may account for the observed differences in apnea prevalence and severity.

200 citations

Journal ArticleDOI
TL;DR: The results showed that the subjects had significantly lower median scores on all eight domains of the SF‐36 than normative data, and scored particularly poorly for the domains of role physical, energy/vitality, and social functioning.
Abstract: Narcolepsy is a chronic sleep disorder characterised by symptoms of excessive daytime sleepiness and cataplexy. The aim of this study was to describe the health-related quality of life of people with narcolepsy residing in the UK. The study comprised a postal survey of 500 members of the UK narcolepsy patient association, which included amongst other questions the UK Short Form 36 (SF-36), the Beck Depression Inventory (BDI), and the Ullanlinna Narcolepsy Scale (UNS). A total of 305 questionnaires were included in the final analysis. The results showed that the subjects had significantly lower median scores on all eight domains of the SF-36 than normative data, and scored particularly poorly for the domains of role physical, energy/vitality, and social functioning. The BDI indicated that 56.9% of subjects had some degree of depression. In addition, many individuals described limitations on their education, home, work and social life caused by their symptoms. There was little difference between the groups receiving different types of medication. This study is the largest of its type in the UK, although the limitations of using a sample from a patient association have been recognised. The results are consistent with studies of narcolepsy in other countries in demonstrating the extensive impact of this disorder on health-related quality of life.

200 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023344
2022644
20211,073
2020954
2019742
2018751